Mitochondrial ribosomal protein L22

39S ribosomal protein L22, mitochondrial is a protein that in humans is encoded by the MRPL22 gene.[5]

MRPL22
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMRPL22, L22mt, MRP-L22, MRP-L25, RPML25, HSPC158, mitochondrial ribosomal protein L22
External IDsOMIM: 611835 MGI: 1333794 HomoloGene: 56664 GeneCards: MRPL22
Orthologs
SpeciesHumanMouse
Entrez

29093

216767

Ensembl

ENSG00000082515

ENSMUSG00000020514

UniProt

Q9NWU5

Q8BU88

RefSeq (mRNA)

NM_014180
NM_001014990

NM_175001

RefSeq (protein)

NP_001014990
NP_054899

NP_778166
NP_001390902

Location (UCSC)Chr 5: 154.94 – 154.97 MbChr 11: 58.06 – 58.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L22 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 4q. Two transcript variants encoding different isoforms have been found for this gene.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000082515 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000020514 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: MRPL22 mitochondrial ribosomal protein L22".

Further reading


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