Mitochondrial ribosomal protein L19

39S ribosomal protein L19, mitochondrial is a protein that in humans is encoded by the MRPL19 gene.[5][6][7]

MRPL19
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMRPL19, L19mt, MRP-L15, MRP-L19, MRPL15, RLX1, RPML15, mitochondrial ribosomal protein L19
External IDsOMIM: 611832 MGI: 1926274 HomoloGene: 8851 GeneCards: MRPL19
Orthologs
SpeciesHumanMouse
Entrez

9801

56284

Ensembl

ENSG00000115364

ENSMUSG00000030045

UniProt

P49406

Q9D338

RefSeq (mRNA)

NM_014763

NM_026490

RefSeq (protein)

NP_055578

NP_080766

Location (UCSC)Chr 2: 75.65 – 75.69 MbChr 6: 81.93 – 81.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000115364 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000030045 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kenmochi N, Suzuki T, Uechi T, Magoori M, Kuniba M, Higa S, Watanabe K, Tanaka T (Sep 2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
  6. Anthoni H, Zucchelli M, Matsson H, Muller-Myhsok B, Fransson I, Schumacher J, Massinen S, Onkamo P, Warnke A, Griesemann H, Hoffmann P, Nopola-Hemmi J, Lyytinen H, Schulte-Korne G, Kere J, Nothen MM, Peyrard-Janvid M (Apr 2007). "A locus on 2p12 containing the co-regulated MRPL19 and C2ORF3 genes is associated to dyslexia". Hum Mol Genet. 16 (6): 667–77. doi:10.1093/hmg/ddm009. PMID 17309879.
  7. "Entrez Gene: MRPL19 mitochondrial ribosomal protein L19".

Further reading


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