40S ribosomal protein S13

40S ribosomal protein S13 is a protein that in humans is encoded by the RPS13 gene.[5][6][7]

RPS13
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRPS13, S13, ribosomal protein S13
External IDsOMIM: 180476 MGI: 1915302 HomoloGene: 128182 GeneCards: RPS13
Orthologs
SpeciesHumanMouse
Entrez

6207

68052

Ensembl

ENSG00000110700

ENSMUSG00000090862

UniProt

P62277

P62301

RefSeq (mRNA)

NM_001017

NM_026533

RefSeq (protein)

NP_001008

NP_080809

Location (UCSC)Chr 11: 17.07 – 17.08 MbChr 7: 115.93 – 115.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S15P family of ribosomal proteins. It is located in the cytoplasm. The protein has been shown to bind to the 5.8S rRNA in rat. The gene product of the E. coli ortholog (ribosomal protein S15) functions at early steps in ribosome assembly. This gene is co-transcribed with two U14 small nucleolar RNA genes, which are located in its third and fifth introns. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[7]

Interactions

RPS13 has been shown to interact with PDCD4.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000110700 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000090862 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Chadeneau C, LeMoullac B, Denis MG (Aug 1993). "Cloning and analysis of the human S13 ribosomal protein cDNA". Nucleic Acids Res. 21 (12): 2945. doi:10.1093/nar/21.12.2945. PMC 309694. PMID 8332508.
  6. Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
  7. "Entrez Gene: RPS13 ribosomal protein S13".
  8. Kang MJ, Ahn HS, Lee JY, Matsuhashi S, Park WY (April 2002). "Up-regulation of PDCD4 in senescent human diploid fibroblasts". Biochem. Biophys. Res. Commun. 293 (1): 617–21. doi:10.1016/S0006-291X(02)00264-4. PMID 12054647.

Further reading

  • Overview of all the structural information available in the PDB for UniProt: P62277 (40S ribosomal protein S13) at the PDBe-KB.
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