Mitochondrial ribosomal protein L20

MRPL20
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3J7Y, 3J9M
Identifiers
Aliases	MRPL20, L20mt, MRP-L20, mitochondrial ribosomal protein L20
External IDs	OMIM: 611833 MGI: 2137221 HomoloGene: 9941 GeneCards: MRPL20
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	1,407,293 bp[1]
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)[2]
End	155,894,432 bp[2]
RNA expression pattern
	Top expressed in
	palpebral conjunctiva; ; germinal epithelium; ; amniotic fluid; ; corpus epididymis; ; Brodmann area 23; ; parietal pleura; ; endothelial cell; ; right ventricle; ; cavity of mouth; ; gastrocnemius muscle;
	Top expressed in
	spermatocyte; ; spermatid; ; morula; ; submandibular gland; ; neural tube; ; ganglionic eminence; ; yolk sac; ; brown adipose tissue; ; endocardial cushion; ; seminal vesicula;
	More reference expression data
	n/a
Gene ontology
Molecular function	rRNA binding; protein binding; RNA binding; structural constituent of ribosome;
Cellular component	mitochondrial inner membrane; ribosome; intracellular anatomical structure; mitochondrial ribosome; mitochondrion; mitochondrial large ribosomal subunit;
Biological process	mitochondrial translational elongation; mitochondrial translational termination; protein biosynthesis; ribosomal large subunit assembly;
	Sources:Amigo / QuickGO
Orthologs
	55052
	66448
	ENSG00000242485
	ENSMUSG00000029066
	Q9BYC9
	Q9CQL4
	NM_017971; NM_001318485
	NM_025570
	NP_001305414; NP_060441
	NP_079846
	Wikidata
View/Edit Human	View/Edit Mouse

39S ribosomal protein L20, mitochondrial is a protein that in humans is encoded by the MRPL20 gene.[5]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 21q.[5]

References

GRCh38: Ensembl release 89: ENSG00000242485 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000029066 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: MRPL20 mitochondrial ribosomal protein L20".

Venter JC, Adams MD, Myers EW, et al. (2001). "The sequence of the human genome". Science. 291 (5507): 1304–51. Bibcode:2001Sci...291.1304V. doi:10.1126/science.1058040. PMID 11181995.
Suzuki T, Terasaki M, Takemoto-Hori C, et al. (2001). "Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria". J. Biol. Chem. 276 (24): 21724–36. doi:10.1074/jbc.M100432200. PMID 11279069.
Kenmochi N, Suzuki T, Uechi T, et al. (2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
Koc EC, Burkhart W, Blackburn K, et al. (2001). "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present". J. Biol. Chem. 276 (47): 43958–69. doi:10.1074/jbc.M106510200. PMID 11551941.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000242485 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029066 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: MRPL20 mitochondrial ribosomal protein L20".

Mitochondrial ribosomal protein L20

References

Further reading