Mitochondrial ribosomal protein L33

39S ribosomal protein L33, mitochondrial is a protein that in humans is encoded by the MRPL33 gene.[5]

MRPL33
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMRPL33, C2orf1, L33mt, MRP-L33, RPL33L, mitochondrial ribosomal protein L33
External IDsOMIM: 610059 MGI: 2137225 HomoloGene: 81733 GeneCards: MRPL33
Orthologs
SpeciesHumanMouse
Entrez

9553

66845

Ensembl

ENSG00000243147

ENSMUSG00000106918

UniProt

O75394

Q9CQP0

RefSeq (mRNA)

NM_145330
NM_004891

NM_025796

RefSeq (protein)

NP_004882
NP_663303

NP_080072

Location (UCSC)Chr 2: 27.77 – 27.99 MbChr 5: 31.75 – 31.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternatively spliced transcript variants encoding different isoforms have been described.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000243147 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000106918 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: MRPL33 mitochondrial ribosomal protein L33".

Further reading

  • Overview of all the structural information available in the PDB for UniProt: O75394 (Human 39S ribosomal protein L33, mitochondrial (MRPL33)) at the PDBe-KB.


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