EIF3B

Eukaryotic translation initiation factor 3 subunit B (eIF3b) is a protein that in humans is encoded by the EIF3B gene.[5][6]

EIF3B
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesEIF3B, EIF3-ETA, EIF3-P110, EIF3-P116, EIF3S9, PRT1, eukaryotic translation initiation factor 3 subunit B
External IDsOMIM: 603917 MGI: 106478 HomoloGene: 2780 GeneCards: EIF3B
Orthologs
SpeciesHumanMouse
Entrez

8662

27979

Ensembl

ENSG00000106263

ENSMUSG00000056076

UniProt

P55884

Q8JZQ9

RefSeq (mRNA)

NM_133916

RefSeq (protein)

NP_001032360
NP_003742
NP_001349720
NP_001349721
NP_001349722

NP_598677

Location (UCSC)Chr 7: 2.35 – 2.38 MbChr 5: 140.41 – 140.43 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

EIF3B has been shown to interact with P70-S6 Kinase 1[7] and EIF3A.[5][8][9][10]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000106263 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000056076 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Méthot N, Rom E, Olsen H, Sonenberg N (February 1997). "The human homologue of the yeast Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170". J. Biol. Chem. 272 (2): 1110–6. doi:10.1074/jbc.272.2.1110. PMID 8995410.
  6. "Entrez Gene: EIF3S9 eukaryotic translation initiation factor 3, subunit 9 eta, 116kDa".
  7. Holz MK, Ballif BA, Gygi SP, Blenis J (November 2005). "mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events". Cell. 123 (4): 569–80. doi:10.1016/j.cell.2005.10.024. PMID 16286006. S2CID 11118504.
  8. Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW (October 2003). "Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3". Eur. J. Biochem. 270 (20): 4133–9. doi:10.1046/j.1432-1033.2003.03807.x. PMID 14519125.
  9. Harris TE, Chi A, Shabanowitz J, Hunt DF, Rhoads RE, Lawrence JC (April 2006). "mTOR-dependent stimulation of the association of eIF4G and eIF3 by insulin". EMBO J. 25 (8): 1659–68. doi:10.1038/sj.emboj.7601047. PMC 1440840. PMID 16541103.
  10. Block KL, Vornlocher HP, Hershey JW (November 1998). "Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3". J. Biol. Chem. 273 (48): 31901–8. doi:10.1074/jbc.273.48.31901. PMID 9822659.

Further reading


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