60S ribosomal protein L28

60S ribosomal protein L28 is a protein that in humans is encoded by the RPL28 gene.[5][6][7]

RPL28
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRPL28, L28, ribosomal protein L28
External IDsOMIM: 603638 MGI: 101839 HomoloGene: 768 GeneCards: RPL28
EC number3.6.5.3
Orthologs
SpeciesHumanMouse
Entrez

6158

19943

Ensembl

ENSG00000108107

ENSMUSG00000030432

UniProt

P46779

P41105

RefSeq (mRNA)

NM_009081

RefSeq (protein)

NP_033107

Location (UCSC)Chr 19: 55.39 – 55.4 MbChr 7: 4.8 – 4.8 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L28E family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000108107 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000030432 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Frigerio JM, Dagorn JC, Iovanna JL (Jul 1995). "Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs". Biochim Biophys Acta. 1262 (1): 64–8. doi:10.1016/0167-4781(95)00045-i. PMID 7772601.
  6. Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
  7. "Entrez Gene: RPL28 ribosomal protein L28".
  • Human RPL28 genome location and RPL28 gene details page in the UCSC Genome Browser.
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human 60S ribosomal protein L28

Further reading

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.