MRPS35

28S ribosomal protein S35, mitochondrial is a protein that in humans is encoded by the MRPS35 gene.[5][6]

MRPS35
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J9M
Identifiers
Aliases	MRPS35, MDS023, MRP-S28, MRPS28, HDCMD11P, mitochondrial ribosomal protein S35
External IDs	OMIM: 611995 MGI: 2385255 HomoloGene: 11048 GeneCards: MRPS35
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p11.22 Start 27,710,822 bp[1] End 27,756,295 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 G3 Start 146,944,262 bp[2] End 146,975,489 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in rectum Achilles tendon tibialis anterior muscle gastrocnemius muscle deltoid muscle right adrenal gland islet of Langerhans left adrenal gland quadriceps femoris muscle vastus lateralis muscle Top expressed in interventricular septum right ventricle myocardium of ventricle proximal tubule duodenum endocardial cushion cardiac muscles brown adipose tissue epithelium of stomach kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of ribosome RNA binding Cellular component mitochondrial inner membrane ribosome mitochondrial small ribosomal subunit mitochondrion Biological process mitochondrial translational elongation mitochondrial translational termination mitochondrial translation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 60488 232536 Ensembl ENSG00000061794 ENSMUSG00000040112 UniProt P82673 Q8BJZ4 RefSeq (mRNA) NM_021821 NM_001190864 NM_145573 RefSeq (protein) NP_001177793 NP_068593 NP_663548 Location (UCSC) Chr 12: 27.71 – 27.76 Mb Chr 6: 146.94 – 146.98 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that has had confusing nomenclature in the literature. Pseudogenes corresponding to this gene are found on chromosomes 3p, 5q, and 10q.[6]