Mitochondrial ribosomal protein L4

39S ribosomal protein L4, mitochondrial is a protein that in humans is encoded by the MRPL4 gene.[5]

MRPL4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMRPL4, CGI-28, L4mt, mitochondrial ribosomal protein L4
External IDsOMIM: 611823 MGI: 2137210 HomoloGene: 32286 GeneCards: MRPL4
Orthologs
SpeciesHumanMouse
Entrez

51073

66163

Ensembl

ENSG00000105364

ENSMUSG00000003299

UniProt

Q9BYD3

Q9DCU6

RefSeq (mRNA)

NM_015956
NM_146387
NM_146388

NM_023167
NM_001357899

RefSeq (protein)

NP_057040
NP_666499
NP_666500
NP_057040.2
NP_666499.1

NP_075656
NP_001344828

Location (UCSC)Chr 19: 10.25 – 10.26 MbChr 9: 20.91 – 20.92 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified alternatively spliced variants that encode different protein isoforms.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000105364 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000003299 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: MRPL4 mitochondrial ribosomal protein L4".

Further reading

  • Overview of all the structural information available in the PDB for UniProt: Q9BYD3 (39S ribosomal protein L4, mitochondrial) at the PDBe-KB.
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