Mitochondrial ribosomal protein L1

MRPL1
Identifiers
Aliases	MRPL1, BM022, L1MT, MRP-L1, mitochondrial ribosomal protein L1
External IDs	OMIM: 611821 MGI: 2137202 HomoloGene: 41355 GeneCards: MRPL1
Gene location (Human)
Chr.	Chromosome 4 (human)[1]
End	77,952,785 bp[1]
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)[2]
End	96,414,586 bp[2]
RNA expression pattern
	Top expressed in
	deltoid muscle; ; quadriceps femoris muscle; ; vastus lateralis muscle; ; tibialis anterior muscle; ; rectum; ; gastrocnemius muscle; ; ganglionic eminence; ; islet of Langerhans; ; right ventricle; ; smooth muscle tissue;
	Top expressed in
	interventricular septum; ; intercostal muscle; ; myocardium of ventricle; ; seminiferous tubule; ; soleus muscle; ; left lobe of liver; ; cumulus cell; ; quadriceps femoris muscle; ; spermatid; ; tibialis anterior muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	structural constituent of ribosome; protein binding; RNA binding; box H/ACA snoRNA binding;
Cellular component	mitochondrial inner membrane; large ribosomal subunit; ribosome; cytosolic large ribosomal subunit; mitochondrion; box H/ACA snoRNP complex;
Biological process	mitochondrial translational elongation; mitochondrial translational termination; maturation of LSU-rRNA; protein biosynthesis; cleavage involved in rRNA processing; rRNA pseudouridine synthesis; snRNA pseudouridine synthesis;
	Sources:Amigo / QuickGO
Orthologs
	65008
	94061
	ENSG00000169288
	ENSMUSG00000029486
	Q9BYD6
	Q99N96
	NM_020236
	NM_001039084; NM_053158
	NP_064621
	NP_001034173; NP_444388
	Wikidata
View/Edit Human	View/Edit Mouse

39S ribosomal protein L1, mitochondrial is a protein that in humans is encoded by the MRPL1 gene.[5]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L1 ribosomal protein family.[5]

References

GRCh38: Ensembl release 89: ENSG00000169288 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000029486 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: MRPL1 mitochondrial ribosomal protein L1".

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Suzuki T, Terasaki M, Takemoto-Hori C, et al. (2001). "Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria". J. Biol. Chem. 276 (24): 21724–36. doi:10.1074/jbc.M100432200. PMID 11279069.
Kenmochi N, Suzuki T, Uechi T, et al. (2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
Choy KW, Wang CC, Ogura A, et al. (2007). "Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes". Physiol. Genomics. 25 (1): 9–15. doi:10.1152/physiolgenomics.00121.2005. PMID 16368877.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000169288 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029486 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: MRPL1 mitochondrial ribosomal protein L1".

Mitochondrial ribosomal protein L1

References

Further reading