Mitochondrial ribosomal protein L13

MRPL13
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3J7Y, 3J9M
Identifiers
Aliases	MRPL13, L13, L13A, L13mt, RPL13, RPML13, mitochondrial ribosomal protein L13
External IDs	OMIM: 610200 MGI: 2137218 HomoloGene: 90894 GeneCards: MRPL13
Gene location (Human)
Chr.	Chromosome 8 (human)[1]
End	120,445,402 bp[1]
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)[2]
End	55,421,144 bp[2]
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; right adrenal gland; ; islet of Langerhans; ; rectum; ; stromal cell of endometrium; ; left adrenal gland; ; Achilles tendon; ; left ventricle; ; right ventricle; ; right lobe of liver;
	Top expressed in
	medial ganglionic eminence; ; maxillary prominence; ; intercostal muscle; ; external carotid artery; ; internal carotid artery; ; right ventricle; ; digastric muscle; ; vas deferens; ; facial motor nucleus; ; Paneth cell;
	More reference expression data
	n/a
Gene ontology
Molecular function	structural constituent of ribosome; protein binding; mRNA binding; RNA binding;
Cellular component	mitochondrial inner membrane; ribosome; mitochondrial ribosome; mitochondrion; mitochondrial large ribosomal subunit;
Biological process	mitochondrial translational elongation; mitochondrial translational termination; protein biosynthesis; negative regulation of translation;
	Sources:Amigo / QuickGO
Orthologs
	28998
	68537
	ENSG00000172172
	ENSMUSG00000022370
	Q9BYD1
	Q9D1P0
	NM_014078
	NM_026759
	NP_054797
	NP_081035
	Wikidata
View/Edit Human	View/Edit Mouse

Mitochondrial ribosomal protein L13 is a protein that in humans is encoded by the MRPL13 gene. [5]

Function

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.

References

GRCh38: Ensembl release 89: ENSG00000172172 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000022370 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Mitochondrial ribosomal protein L13". Retrieved 2017-07-05.

Mitochondrial ribosomal protein L13

Function

References

Further reading