60S ribosomal protein L17

Large ribosomal subunit protein uL22 is a protein that in humans is encoded by the RPL17 gene.[5][6][7]

RPL17
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRPL17, L17, PD-1, RPL23, ribosomal protein L17
External IDsOMIM: 603661 MGI: 2448270 HomoloGene: 115574 GeneCards: RPL17
Orthologs
SpeciesHumanMouse
Entrez

6139

319195

Ensembl

ENSG00000265681

ENSMUSG00000062328

UniProt

P18621

Q9CPR4
Q6ZWZ7

RefSeq (mRNA)

NM_001002239

RefSeq (protein)

NP_001002239
NP_001392893
NP_001392894
NP_001392895

Location (UCSC)Chr 18: 49.49 – 49.49 MbChr 18: 75.13 – 75.14 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22P family of ribosomal proteins. It is located in the cytoplasm. This gene has been referred to as RPL23 because the encoded protein shares amino acid identity with ribosomal protein L23 from Haloarcula marismortui; however, its official symbol is RPL17. Two alternative splice variants have been observed, each encoding the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[7]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000265681 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000062328 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Mager DL, Freeman JD (Oct 1990). "A human gene related to the ribosomal protein L23 gene of Halobacterium marismortui". Nucleic Acids Res. 18 (17): 5301. doi:10.1093/nar/18.17.5301. PMC 332174. PMID 2402465.
  6. Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
  7. "Entrez Gene: RPL17 ribosomal protein L17".

Further reading

  • Overview of all the structural information available in the PDB for UniProt: P18621 (Human 60S ribosomal protein L17) at the PDBe-KB.
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