60S ribosomal protein L39

RPL39
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4UG0, 4V6X, 5AJ0, 3J92, 4UJC, 3J7P, 4UJE, 3J7Q, 3J7R, 4D67, 4UJD, 4V5Z, 4D5Y, 3J7O
Identifiers
Aliases	RPL39, L39, RPL39P42, RPL39_23_1806, ribosomal protein L39
External IDs	OMIM: 300899 MGI: 1914498 HomoloGene: 133571 GeneCards: RPL39
Gene location (Human)
Chr.	X chromosome (human)[1]
End	119,791,630 bp[1]
Gene location (Mouse)
Chr.	X chromosome (mouse)[2]
End	36,349,055 bp[2]
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; endometrium; ; skin of abdomen; ; subcutaneous adipose tissue; ; lymph node; ; spleen; ; right adrenal gland; ; rectum; ; right uterine tube; ; vagina;
	Top expressed in
	yolk sac; ; ganglionic eminence; ; lip; ; esophagus; ; uterus; ; duodenum; ; urinary bladder; ; jejunum; ; bone marrow; ; neural tube;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	RNA binding; structural constituent of ribosome;
Cellular component	ribosome; cytosol; intracellular anatomical structure; extracellular space; cytosolic large ribosomal subunit; polysomal ribosome;
Biological process	SRP-dependent cotranslational protein targeting to membrane; innate immune response in mucosa; viral transcription; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; translational initiation; protein biosynthesis; rRNA processing; antimicrobial humoral immune response mediated by antimicrobial peptide; cytoplasmic translation;
	Sources:Amigo / QuickGO
Orthologs
	6170
	67248
	ENSG00000198918
	ENSMUSG00000079641
	P62891
	P62892
	NM_001000
	NM_026055
	NP_000991
	NP_080331
	Wikidata
View/Edit Human	View/Edit Mouse

60S ribosomal protein L39 is a protein that in humans is encoded by the RPL39 gene.[5][6]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the S39E family of ribosomal proteins. It is located in the cytoplasm. In rat, the protein is the smallest, and one of the most basic, proteins of the ribosome. This gene is co-transcribed with the U69 small nucleolar RNA gene, which is located in its second intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[6]

References

GRCh38: Ensembl release 89: ENSG00000198918 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000079641 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Otsuka S, Tanaka M, Saito S, Yoshimoto K, Itakura M (Sep 1996). "Molecular cloning of a cDNA encoding human ribosomal protein L39". Biochim Biophys Acta. 1308 (2): 119–21. doi:10.1016/0167-4781(96)00106-6. PMID 8764829.
"Entrez Gene: RPL39 ribosomal protein L39".

Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Yoshihama M, Uechi T, Asakawa S, et al. (2002). "The Human Ribosomal Protein Genes: Sequencing and Comparative Analysis of 73 Genes". Genome Res. 12 (3): 379–90. doi:10.1101/gr.214202. PMC 155282. PMID 11875025.
Uechi T, Tanaka T, Kenmochi N (2001). "A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders". Genomics. 72 (3): 223–30. doi:10.1006/geno.2000.6470. PMID 11401437.
Tsui SK, Lee SM, Fung KP, et al. (1997). "Primary structures and sequence analysis of human ribosomal proteins L39 and S27". Biochem. Mol. Biol. Int. 40 (3): 611–6. doi:10.1080/15216549600201203. PMID 8908372. S2CID 7909023.
Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID 7821789.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000198918 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000079641 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8764829-5] Otsuka S, Tanaka M, Saito S, Yoshimoto K, Itakura M (Sep 1996). "Molecular cloning of a cDNA encoding human ribosomal protein L39". Biochim Biophys Acta. 1308 (2): 119–21. doi:10.1016/0167-4781(96)00106-6. PMID 8764829.

[entrez-6] "Entrez Gene: RPL39 ribosomal protein L39".

60S ribosomal protein L39

References

Further reading