60S acidic ribosomal protein P0

60S acidic ribosomal protein P0 is a protein that in humans is encoded by the RPLP0 gene.[5][6]

RPLP0
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRPLP0, L10E, LP0, P0, PRLP0, RPP0, ribosomal protein lateral stalk subunit P0
External IDsOMIM: 180510 MGI: 1927636 HomoloGene: 6517 GeneCards: RPLP0
Orthologs
SpeciesHumanMouse
Entrez

6175

11837

Ensembl

ENSG00000089157

ENSMUSG00000067274

UniProt

P05388

P14869

RefSeq (mRNA)

NM_053275
NM_001002

NM_007475

RefSeq (protein)

NP_000993
NP_444505
NP_000993.1
NP_444505.1

NP_031501

Location (UCSC)Chr 12: 120.2 – 120.2 MbChr 5: 115.7 – 115.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ribosomes catalyze protein synthesis and consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which is the functional equivalent of the E. coli L10 ribosomal protein, belongs to the L10P family of ribosomal proteins. It is a neutral phosphoprotein with a C-terminal end that is nearly identical to the C-terminal ends of the acidic ribosomal phosphoproteins P1 and P2. The P0 protein can interact with P1 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. Transcript variants derived from alternative splicing exist; they encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000089157 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000067274 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
  6. "Entrez Gene: RPLP0 ribosomal protein, large, P0".

Further reading

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