40S ribosomal protein S16

40S ribosomal protein S16' is a protein that in humans is encoded by the RPS16 gene.[5][6][7]

RPS16
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRPS16, S16, ribosomal protein S16
External IDsOMIM: 603675 MGI: 98118 HomoloGene: 794 GeneCards: RPS16
Orthologs
SpeciesHumanMouse
Entrez

6217

20055

Ensembl

ENSG00000105193

ENSMUSG00000037563

UniProt

P62249

P14131

RefSeq (mRNA)

NM_001020
NM_001321111
NM_001363860

NM_013647

RefSeq (protein)

NP_001011
NP_001308040
NP_001350789

NP_038675

Location (UCSC)Chr 19: 39.43 – 39.44 MbChr 7: 28.05 – 28.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Length: 146 amino acids

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S9P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[7]

Interactions

Ribosomal protein S16 is one of the proteins from the small ribosomal subunit. It belongs to a ribosomal protein family that is divided into three groups based on sequence similarity:

* Eubacterial S16.

* Algal and plant chloroplast S16.

* Cyanelle S16.

* Neurospora crassa mitochondrial S24 (cyt-21).

S16 proteins have about 100 amino-acid residues. There are two paralogues in Arabidopsis thaliana, RPS16-1 (chloroplastic) and RPS16-2 (targeted to the chloroplast and the mitochondrion)

[4].

RPS16 has been shown to interact with CDC5L.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000105193 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000037563 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Batra SK, Metzgar RS, Hollingsworth MA (May 1991). "Molecular cloning and sequence analysis of the human ribosomal protein S16". J Biol Chem. 266 (11): 6830–3. doi:10.1016/S0021-9258(20)89575-1. PMID 2016298.
  6. Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (August 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
  7. "Entrez Gene: RPS16 ribosomal protein S16".
  8. Ajuh, P; Kuster B; Panov K; Zomerdijk J C; Mann M; Lamond A I (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. ENGLAND. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. ISSN 0261-4189. PMC 305846. PMID 11101529.

Further reading



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