Desmethylcitalopram

Desmethylcitalopram
Clinical data
ATC code	none;
Legal status
Legal status	In general: uncontrolled;
Pharmacokinetic data
Elimination half-life	50 h
Identifiers
	IUPAC name (RS/S)-1-[3-(Methylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile;
CAS Number	62498-67-3 ;
PubChem CID	162180;
ChemSpider	142424 ;
UNII	3KBX9104IR;
CompTox Dashboard (EPA)	DTXSID90881082 ;
ECHA InfoCard	100.057.776
Chemical and physical data
Formula	C19H19FN2O
Molar mass	310.372 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CNCCCC1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F;
	InChI InChI=1S/C19H19FN2O/c1-22-10-2-9-19(16-4-6-17(20)7-5-16)18-8-3-14(12-21)11-15(18)13-23-19/h3-8,11,22H,2,9-10,13H2,1H3 ; Key:PTJADDMMFYXMMG-UHFFFAOYSA-N ;
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Desmethylcitalopram is an active metabolite of the antidepressant drugs citalopram (racemic) and escitalopram (the S-enantiomer, which would be called desmethylescitalopram).[1][2] Like citalopram and escitalopram, desmethylcitalopram functions as a selective serotonin reuptake inhibitor (SSRI), and is responsible for some of its parents' therapeutic benefits.

References

"Desmethylcitalopram". Human Metabolome Database.
Brøsen K, Naranjo CA (August 2001). "Review of pharmacokinetic and pharmacodynamic interaction studies with citalopram". European Neuropsychopharmacology. 11 (4): 275–83. doi:10.1016/s0924-977x(01)00101-8. PMID 11532381. S2CID 11837037.

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