Hydroxetamine

Hydroxetamine (3'-hydroxy-2-oxo-PCE, O-desmethylmethoxetamine, HXE) is a recreational designer drug from the arylcyclohexylamine family, with dissociative effects. It is known as an active metabolite of the dissociative designer drug methoxetamine,[1][2] but has also been sold in its own right since late 2019.[3]

Hydroxetamine
Legal status
Legal status
  • CA: HXE is not specifically scheduled but ketamine and its analogues are schedule I
  • DE: NpSG (Industrial and scientific use only)
  • UK: Class B
Identifiers
IUPAC name
  • 2-(ethylamino)-2-(3-hydroxyphenyl)cyclohexan-1-one
CAS Number
ChemSpider
Chemical and physical data
FormulaC14H19NO2
Molar mass233.311 g·mol−1
3D model (JSmol)
SMILES
  • O=C1CCCCC1(NCC)C2=CC(O)=CC=C2
InChI
  • InChI=1S/C14H19NO2/c1-2-15-14(9-4-3-8-13(14)17)11-6-5-7-12(16)10-11/h5-7,10,15-16H,2-4,8-9H2,1H3
  • Key:CQERUJSORROCGH-UHFFFAOYSA-N

See also

References
  1. Menzies EL, Hudson SC, Dargan PI, Parkin MC, Wood DM, Kicman AT (June 2014). "Characterizing metabolites and potential metabolic pathways for the novel psychoactive substance methoxetamine". Drug Testing and Analysis. 6 (6): 506–15. doi:10.1002/dta.1541. PMID 24574323.
  2. Horsley RR, Lhotkova E, Hajkova K, Jurasek B, Kuchar M, Palenicek T (September 2016). "Detailed pharmacological evaluation of methoxetamine (MXE), a novel psychoactive ketamine analogue-Behavioural, pharmacokinetic and metabolic studies in the Wistar rat". Brain Research Bulletin. 126 (Pt 1): 102–110. doi:10.1016/j.brainresbull.2016.05.002. PMID 27155360. S2CID 3955788.
  3. Alert from NDEWS Web Monitoring Team: Increases in Reddit discussions of HXE in February-May of 2021. National Drug Early Warning System, Issue 39, 11 June 2021. University of Florida, funded by the National Institute on Drug Abuse



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