List of antidepressants

This is a complete list of clinically approved prescription antidepressants throughout the world, as well as clinically approved prescription drugs used to augment antidepressants or mood stabilizers, by pharmacological and/or structural classification. Chemical/generic names are listed first, with brand names in parentheses. All drugs listed are approved specifically for major depressive disorder unless noted otherwise.

Selective serotonin reuptake inhibitors (SSRIs)

Discontinued/withdrawn

Serotonin–norepinephrine reuptake inhibitors (SNRIs)

Serotonin modulators and stimulators (SMSs)

Serotonin antagonist and reuptake inhibitors (SARIs)

  • Nefazodone (Dutonin, Nefadar, Serzone) – withdrawn/discontinued in most countries
  • Trazodone (Desyrel)

Discontinued/withdrawn

Norepinephrine reuptake inhibitors (NRIs)

Off-label only

Norepinephrine–dopamine reuptake inhibitors (NDRIs)

Off-label only

Discontinued/withdrawn

Tricyclic antidepressants (TCAs)

Amineptine (Survector, Maneon) and tianeptine (Stablon, Coaxil) are technically TCAs but are atypical, and are grouped elsewhere.

Discontinued/withdrawn

Tetracyclic antidepressants (TeCAs)

Mianserin, mirtazapine, and setiptiline are also sometimes described as noradrenergic and specific serotonergic antidepressants (NaSSAs).

Monoamine oxidase inhibitors (MAOIs)

Irreversible

Non-selective

Discontinued/withdrawn

Selective for MAO-B

Reversible

Non-selective

Discontinued/withdrawn

Selective for MAO-A

These drugs are sometimes described as reversible inhibitors of MAO-A (RIMAs).

Discontinued/withdrawn

Mixed

Non-selective

  • Bifemelane (Alnert, Celeport) – RIMA, irreversible inhibitor of MAO-B, and weak NRI

Atypical antipsychotics

Others

Marketed

Off-label only

Discontinued/withdrawn

Over-the-counter

The following antidepressants are available both with a prescription and over-the-counter:

  • Ademetionine [S-Adenosyl-L-methionine (SAMe)] (Heptral, Transmetil, Samyl) – cofactor in monoamine neurotransmitter biosynthesis
  • Hypericum perforatum [St. John's Wort (SJW)] (Jarsin, Kira, Movina) – TRPC6 activator, and various other actions
  • Oxitriptan [5-Hydroxytryptophan (5-HTP)] (Cincofarm, Levothym, Triptum) – precursor in serotonin biosynthesis
  • Tryptophan (Tryptan, Optimax, Aminomine) – precursor in serotonin biosynthesis

Adjunctive treatments

Atypical antipsychotics

  • Aripiprazole (Abilify) – approved as an adjunct to antidepressant for major depression
  • Brexpiprazole (Rexulti) – approved as an adjunct to antidepressant for major depression
  • Lumateperone (Caplyta) – approved as an adjunct to mood stabilizer for bipolar depression
  • Lurasidone (Latuda) – approved as an adjunct to mood stabilizer for bipolar depression
  • Olanzapine (Zyprexa) – approved as an adjunct to antidepressant for major depression
  • Quetiapine (Seroquel) – approved as an adjunct to antidepressant or mood stabilizer for major depression and bipolar depression

Off-label only

Typical antipsychotics

Off-label only

Others

Off-label only

Combination products

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