Desvenlafaxine

Desvenlafaxine
Skeletal formula
Ball-and-stick model of desvenlafaxine
Names
Trade namesPristiq, Desfax, Ellefore, others
Other namesO-desmethylvenlafaxine
IUPAC name
  • 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)
    ethyl]phenol
Clinical data
Drug classSerotonin-norepinephrine reuptake inhibitor[1]
Main usesMajor depression[1]
WHO AWaReUnlinkedWikibase error: ⧼unlinkedwikibase-error-statements-entity-not-set⧽
Pregnancy
category
  • AU: B2
  • US: C (Risk not ruled out)
    Routes of
    use    		By mouth
    Defined daily dose50 mg[2]
    External links
    AHFS/Drugs.comMonograph
    MedlinePlusa608022
    Legal
    License data
    Legal status
    Pharmacokinetics
    Bioavailability80%
    Protein bindingLow (30%)
    MetabolismCYP3A4, (CYP2D6 is not involved)
    Elimination half-life11 h
    Excretion45% excreted unchanged in urine
    Chemical and physical data
    FormulaC16H25NO2
    Molar mass263.381 g·mol−1
    3D model (JSmol)
    SMILES
    • OC2(C(c1ccc(O)cc1)CN(C)C)CCCCC2
    InChI
    • InChI=1S/C16H25NO2/c1-17(2)12-15(13-6-8-14(18)9-7-13)16(19)10-4-3-5-11-16/h6-9,15,18-19H,3-5,10-12H2,1-2H3 checkY
    • Key:KYYIDSXMWOZKMP-UHFFFAOYSA-N checkY

    Desvenlafaxine, sold under the brand name Pristiq among others, is a medication used to treat major depressive disorder.[1] It is recommended that the need for further treatment be occasionally reassessed.[1] It appears less effective than its parent compound venlafaxine.[3] It is taken by mouth.[1]

    Common side effects include dizziness, trouble sleeping, increased sweating, constipation, sleepiness, anxiety, and sexual problems.[1] Serious side effects may include suicide in those under the age of 25, serotonin syndrome, bleeding, mania, and high blood pressure.[1] A withdrawal syndrome may occur if the dose is rapidly decreased.[1] It is unclear if use during pregnancy or breastfeeding is safe.[4] It is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class.[1]

    Desvenlafaxine was approved for medical use in the United States in 2008.[1] Use in Europe was declined in 2009.[3] In the United States the wholesale cost is about 25.20 USD per month.[5] In 2017, it was the 235th most commonly prescribed medication in the United States, with more than two million prescriptions.[6][7]

    Medical uses

    Desvenlafaxine is primarily used as a treatment for major depressive disorder.[8] Use has only been studied up to 8 weeks.[1] It may be less effective than venlafaxine,[3] although some studies have found comparable efficacy with a lower rate of nausea.[9]

    Doses of 50–400 mg/day appear effective for major depressive disorder, although no additional benefit was demonstrated at doses greater than 50 mg/day, and adverse events and discontinuations were more frequent at higher doses.[10]

    Desvenlafaxine improves the HAM-D17 score[11] and measures of well being such as the Sheehan Disability Scale (SDS) and 5-item World Health Organization Well-Being Index (WHO-5).[12]

    Dosage

    The defined daily dose is 50 mg by mouth.[2]

    Side effects

    Frequency of side effects:[8][13][14]

    Very common:

    • Nausea
    • Headache
    • Dizziness
    • Dry mouth
    • Hyperhidrosis
    • Diarrhea
    • Insomnia
    • Constipation
    • Fatigue

    Common:

    • Tremor
    • Blurred vision
    • Mydriasis
    • Decreased appetite
    • Sexual dysfunction
    • Insomnia
    • Anxiety
    • Elevated cholesterol and triglycerides
    • Proteinuria
    • Vertigo
    • Feeling jittery
    • Asthenia
    • Nervousness
    • Hot flush
    • Irritability
    • Abnormal dreams
    • Urinary hesitation
    • Yawning
    • Rash

    Uncommon:

    Rare:

    Common however unknown intensity:

    Pharmacology

    Desvenlafaxine is a synthetic form of the isolated major active metabolite of venlafaxine, and is categorized as a serotonin-norepinephrine reuptake inhibitor (SNRI). When most normal metabolizers take venlafaxine, approximately 70% of the dose is metabolized into desvenlafaxine, so the effects of the two drugs are expected to be very similar.[15] It works by blocking the "reuptake" transporters for key neurotransmitters affecting mood, thereby leaving more active neurotransmitters in the synapse. The neurotransmitters affected are serotonin (5-hydroxytryptamine) and norepinephrine (noradrenaline). It is approximately 10 times more potent at inhibiting serotonin uptake than norepinephrine uptake.[16]

    TransporterKi[nM][16][17] IC50 [nM][16]
    SERT40.247.3
    NET558.4531.3

    Society and culture

    Cost

    In the United States the wholesale cost is about 25.20 USD per month.[5] In 2017, it was the 235th most commonly prescribed medication in the United States, with more than two million prescriptions.[6][7]

    • Desvenlafaxine costs (US)
      Desvenlafaxine costs (US)
    • Desvenlafaxine prescriptions (US)
      Desvenlafaxine prescriptions (US)

    Approval status

    United States

    Pristiq 50 mg tablets (US)

    Wyeth announced on 23 January 2007 that it received an approvable letter from the Food and Drug Administration for desvenlafaxine. Final approval to sell the drug was contingent on a number of things, including:

    • A satisfactory FDA inspection of Wyeth's Guayama, Puerto Rico facility, where the drug is to be manufactured;
    • Several postmarketing surveillance commitments, and follow-up studies on low-dose use, relapse, and use in children;
    • Clarity by Wyeth around the company's product education plan for physicians and patients;
    • Approval of desvenlafaxine's proprietary name, Pristiq.[18]

    The FDA approved the drug for antidepressant use in February 2008, and was to be available in US pharmacies in May 2008.[19]

    In March 2017, the generic form of the drug was made available in the US.

    Canada

    On February 4, 2009, Health Canada approved use of desvenlafaxine for treatment of depression.[20][21]

    European Union

    In 2009, an application to market desvenlafaxine for major depressive disorder in the European Union was declined.[3] In 2012, Pfizer received authorization in Spain to market desvenlafaxine for the disorder but it is not being sold.[22][23]

    Australia

    Desvenlafaxine is classified as a schedule 4 (prescription only) drug in Australia. It was listed on the PBS (Pharmaceutical Benefits Scheme) in 2008 for the treatment of major depressive disorders.[24]

    See also

    References

    1. 1 2 3 4 5 6 7 8 9 10 11 "Desvenlafaxine Succinate Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 29 March 2019. Retrieved 18 March 2019.
    2. 1 2 "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 21 January 2021. Retrieved 7 September 2020.
    3. 1 2 3 4 "Withdrawal Assessment Report for Dessvenlafaxime" (PDF). EMA. p. 3. Archived (PDF) from the original on 22 March 2019. Retrieved 22 March 2019.
    4. ↑ "Desvenlafaxine Pregnancy and Breastfeeding Warnings". Drugs.com. Archived from the original on 29 November 2018. Retrieved 19 March 2019.
    5. 1 2 "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 2019-03-06. Retrieved 3 March 2019.
    6. 1 2 "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.
    7. 1 2 "Desvenlafaxine - Drug Usage Statistics". ClinCalc. Archived from the original on 12 April 2020. Retrieved 11 April 2020.
    8. 1 2 "PRODUCT INFORMATION – PRISTIQ desvenlafaxine (as succinate)" (PDF). TGA eBusiness Services. Pfizer Australia Pty Ltd. 10 December 2012. Archived from the original on 7 April 2019. Retrieved 8 November 2013.
    9. ↑ Coleman, Kristina A.; Xavier, Vanessa Y.; Palmer, Trish L.; Meaney, James V.; Radalj, Libby M.; Canny, Louise M. (2012). "An indirect comparison of the efficacy and safety of desvenlafaxine and venlafaxine using placebo as the common comparator". CNS Spectrums. 17 (3): 131–141. doi:10.1017/S1092852912000648. ISSN 2165-6509. Archived from the original on 2018-06-14. Retrieved 2019-11-06.
    10. ↑ Perry, Richard; Cassagnol, Manouchkathe (2009). "Desvenlafaxine: a new serotonin-norepinephrine reuptake inhibitor for the treatment of adults with major depressive disorder". Clinical Therapeutics. 31 Pt 1: 1374–1404. doi:10.1016/j.clinthera.2009.07.012. ISSN 1879-114X. PMID 19698900.
    11. ↑ Thase ME, Kornstein SG, Germain JM, Jiang Q, Guico-Pabia C, Ninan PT (March 2009). "An integrated analysis of the efficacy of desvenlafaxine compared with placebo in patients with major depressive disorder". CNS Spectr. 14 (3): 144–54. PMID 19407711.
    12. ↑ Soares CN, Kornstein SG, Thase ME, Jiang Q, Guico-Pabia CJ (October 2009). "Assessing the efficacy of desvenlafaxine for improving functioning and well-being outcome measures in patients with major depressive disorder: a pooled analysis of 9 double-blind, placebo-controlled, 8-week clinical trials". J Clin Psychiatry. 70 (10): 1365–71. doi:10.4088/JCP.09m05133blu. PMID 19906341.
    13. ↑ "DESVENLAFAXINE tablet, extended release [Ranbaxy Pharmaceuticals Inc.]". DailyMed. Ranbaxy Pharmaceuticals Inc. March 2013. Archived from the original on 4 July 2013. Retrieved 9 November 2013.
    14. ↑ "desvenlafaxine (Rx) - Pristiq, Khedezla". Medscape Reference. WebMD. Archived from the original on 15 December 2013. Retrieved 9 November 2013.
    15. ↑ Lemke, Thomas L.; Williams, David A. (2012). Foye's Principles of Medicinal Chemistry. Lippincott Williams & Wilkins. p. 609. ISBN 978-1-60913-345-0.
    16. 1 2 3 Deecher, DC; Beyer, CE; Johnston, G; Bray, J; Shah, S; Abou-Gharbia, M; Andree, TH (August 2006). "Desvenlafaxine succinate: A new serotonin and norepinephrine reuptake inhibitor" (PDF). The Journal of Pharmacology and Experimental Therapeutics. 318 (2): 657–665. doi:10.1124/jpet.106.103382. PMID 16675639. Archived from the original on 2021-08-28. Retrieved 2013-11-08.
    17. ↑ Roth, BL; Driscol, J (Dec 2012). "PDSP Ki Database". Psychoactive Drug Screening Program (PDSP). University of North Carolina at Chapel Hill and the United States National Institute of Mental Health. Archived from the original on 28 August 2021. Retrieved 7 July 2018.
    18. ↑ "Wyeth Receives Approvable Letter From FDA For Pristiq (Desvenlafaxine Succinate) For The Treatment Of Major Depressive Disorder" (Press release). 2007-01-23. Archived from the original on 2007-02-21. Retrieved 2007-04-04.
    19. ↑ "FDA Approves Pristiq" (Press release). Wyeth. 2008-02-29. Archived from the original on 2008-03-05. Retrieved 2008-02-29.
    20. ↑ Health Canada Notice of Compliance - Pristiq. February 4, 2009, retrieved on March 9, 2009.
    21. ↑ "Summary Basis of Decision (SBD) PrPristiq". Health Canada. 2009-05-29. Archived from the original on 2016-10-18. Retrieved 2016-12-30.
    22. ↑ "Pristiq 100 mg Comprimidos de Liberacion Prolongada". AEMPS Medicines Online Information Center - CIMA. Archived from the original on 2016-03-04. Retrieved 2016-12-30.
    23. ↑ "Pristiq 50 mg Comprimidos de Liberacion Prolongada". AEMPS Medicines Online Information Center - CIMA. Archived from the original on 2015-07-23. Retrieved 2016-12-30.
    24. ↑ Health, Australian Government Department of. "Pharmaceutical Benefits Scheme (PBS) | Desvenlafaxine succinate, tablet, (extended release), 50 mg and 100 mg (base), Pristiq®, November 2008". Australian Government Department of Health. Archived from the original on 27 March 2020. Retrieved 16 February 2021.
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