Alpha-1D adrenergic receptor

The alpha-1D adrenergic receptor1D adrenoreceptor), also known as ADRA1D, is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it.[5]

ADRA1D
Identifiers
AliasesADRA1D, ADRA1, ADRA1A, ADRA1R, ALPHA1, DAR, dJ779E11.2, adrenoceptor alpha 1D
External IDsOMIM: 104219 MGI: 106673 HomoloGene: 551 GeneCards: ADRA1D
Orthologs
SpeciesHumanMouse
Entrez

146

11550

Ensembl

ENSG00000171873

ENSMUSG00000027335

UniProt

P25100

P97714

RefSeq (mRNA)

NM_000678

NM_013460

RefSeq (protein)

NP_000669
NP_000669.1

NP_038488

Location (UCSC)Chr 20: 4.22 – 4.25 MbChr 2: 131.39 – 131.4 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Receptor

There are 3 alpha-1 adrenergic receptor subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. They activate mitogenic responses and regulate growth and proliferation of many cells.

Gene

This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region.[5]

Ligands

Antagonists

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000171873 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000027335 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: ADRA1D adrenergic, alpha-1D-, receptor".
  6. Buckner SA, Milicic I, Daza A, Lynch JJ, Kolasa T, Nakane M, Sullivan JP, Brioni JD (2001). "A-315456: a selective alpha(1D)-adrenoceptor antagonist with minimal dopamine D(2) and 5-HT(1A) receptor affinity". Eur. J. Pharmacol. 433 (1): 123–7. doi:10.1016/s0014-2999(01)01519-9. PMID 11755142.
  7. Cleary L, Murad K, Bexis S, Docherty JR (2005). "The alpha (1D)-adrenoceptor antagonist BMY 7378 is also an alpha (2C)-adrenoceptor antagonist". Autonomic and Autacoid Pharmacology. 25 (4): 135–41. doi:10.1111/j.1474-8673.2005.00342.x. PMID 16176444.

Further reading


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