Prokineticin receptor
The prokineticin receptor is a G protein-coupled receptor which binds the peptide hormone prokineticin. There are two variants each encoded by a different gene (PROKR1, PROKR2).[1] These receptors mediate gastrointestinal smooth muscle contraction and angiogenesis.
| prokineticin receptor 1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | PROKR1 | ||||||
| Alt. symbols | GPR73 | ||||||
| NCBI gene | 10887 | ||||||
| HGNC | 4524 | ||||||
| OMIM | 607122 | ||||||
| RefSeq | NM_138964 | ||||||
| UniProt | Q8TCW9 | ||||||
| Other data | |||||||
| Locus | Chr. 2 p14 | ||||||
| |||||||
| prokineticin receptor 2 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | PROKR2 | ||||||
| Alt. symbols | GPR73L1 | ||||||
| NCBI gene | 128674 | ||||||
| HGNC | 15836 | ||||||
| OMIM | 607123 | ||||||
| RefSeq | NM_144773 | ||||||
| UniProt | Q8NFJ6 | ||||||
| Other data | |||||||
| Locus | Chr. 20 p12.3 | ||||||
| |||||||
References
- Lin DC, Bullock CM, Ehlert FJ, Chen JL, Tian H, Zhou QY (2002). "Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins/endocrine gland vascular endothelial growth factor". J. Biol. Chem. 277 (22): 19276–80. doi:10.1074/jbc.M202139200. PMID 11886876.
External links
- "Prokineticin Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
- PROKR1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- PROKR2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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