Bradykinin receptor B2

Bradykinin receptor B2 is a G-protein coupled receptor for bradykinin, encoded by the BDKRB2 gene in humans.

BDKRB2
Identifiers
AliasesBDKRB2, B2R, BK-2, BK2, BKR2, BRB2, bradykinin receptor B2
External IDsOMIM: 113503 MGI: 102845 HomoloGene: 519 GeneCards: BDKRB2
Orthologs
SpeciesHumanMouse
Entrez

624

12062

Ensembl

ENSG00000168398

ENSMUSG00000021070

UniProt

P30411

P32299

RefSeq (mRNA)

NM_000623
NM_001379692

NM_009747

RefSeq (protein)

NP_000614
NP_001366621

NP_033877

Location (UCSC)Chr 14: 96.2 – 96.24 MbChr 12: 105.53 – 105.56 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mechanism

The B2 receptor is a G protein-coupled receptor, probably coupled to Gq and Gi. Gq stimulates phospholipase C to increase intracellular free calcium and Gi inhibits adenylate cyclase. Furthermore, the receptor stimulates the mitogen-activated protein kinase pathways. It is ubiquitously and constitutively expressed in healthy tissues.

The B2 receptor forms a complex with angiotensin converting enzyme (ACE), and this is thought to play a role in cross-talk between the renin-angiotensin system (RAS) and the kinin–kallikrein system (KKS). The heptapeptide angiotensin (1-7) also potentiates bradykinin action on B2 receptors.[5]

Kallidin also signals through the B2 receptor. An antagonist for the receptor is Hoe 140 (icatibant).[6]

Function

The 9 amino acid bradykinin peptide elicits several responses including vasodilation, edema, smooth muscle spasm and nociceptor stimulation.

Gene

Alternate start codons result in two isoforms of the protein.[7]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000168398 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000021070 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Fernandes L, Fortes ZB, Nigro D, Tostes RC, Santos RA, Catelli De Carvalho MH (2001). "Potentiation of bradykinin by angiotensin-(1-7) on arterioles of spontaneously hypertensive rats studied in vivo". Hypertension. 37 (2 Part 2): 703–9. doi:10.1161/01.hyp.37.2.703. PMID 11230360.
  6. Wirth K, Hock FJ, Albus U, Linz W, Alpermann HG, Anagnostopoulos H, Henk S, Breipohl G, König W, Knolle J (1991). "Hoe 140 a new potent and long acting bradykinin-antagonist: in vivo studies". Br. J. Pharmacol. 102 (3): 774–7. doi:10.1111/j.1476-5381.1991.tb12249.x. PMC 1917928. PMID 1364852.
  7. "Entrez Gene: BDKRB2 bradykinin receptor B2".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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