Glucagon-like peptide-2 receptor

Glucagon-like peptide-2 receptor (GLP-2R) is a protein that in human is encoded by the GLP2R gene located on chromosome 17.[5]

GLP2R
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGLP2R, entrez:9340, glucagon like peptide 2 receptor
External IDsOMIM: 603659 MGI: 2136733 HomoloGene: 3132 GeneCards: GLP2R
Orthologs
SpeciesHumanMouse
Entrez

9340

93896

Ensembl

ENSG00000065325

ENSMUSG00000049928

UniProt

O95838

Q5IXF8

RefSeq (mRNA)

NM_004246

NM_175681

RefSeq (protein)

NP_004237

NP_783612

Location (UCSC)Chr 17: 9.82 – 9.89 MbChr 11: 67.55 – 67.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The GLP2 receptor (GLP2R) is a G protein-coupled receptor superfamily member closely related to the glucagon receptor (GLP1 receptor). Glucagon-like peptide-2 (GLP2) is a 33-amino acid proglucagon-derived peptide produced by intestinal enteroendocrine cells. Like glucagon-like peptide-1 (GLP1) and glucagon itself, it is derived from the proglucagon peptide encoded by the GCG gene. GLP2 stimulates intestinal growth and upregulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. Moreover, GLP2 prevents intestinal hypoplasia resulting from total parenteral nutrition. GLP2R, a G protein-coupled receptor superfamily member is expressed in the gut and closely related to the glucagon receptor (GCGR) and the receptor for GLP1 (GLP1R).[6]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000065325 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000049928 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Brubaker PL, Drucker DJ (2002). "Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors". Receptors & Channels. 8 (3–4): 179–88. doi:10.1080/10606820213687. PMID 12529935.
  6. "Entrez Gene: Glucagon-like peptide 2 receptor".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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