Relaxin receptor

The relaxin receptors are a subclass of four closely related G protein-coupled receptors (GPCR) that bind relaxin peptide hormones.[1][2]

relaxin/insulin-like family peptide receptor 1
Identifiers
SymbolRXFP1
Alt. symbolsLGR7
NCBI gene59350
HGNC19718
OMIM606654
RefSeqNM_021634
UniProtQ9HBX9
Other data
LocusChr. 4 q31.3
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relaxin/insulin-like family peptide receptor 2
Identifiers
SymbolRXFP2
Alt. symbolsLGR8, GREAT, GPR106, INSL3R
NCBI gene122042
HGNC17318
OMIM606655
RefSeqNM_130806
UniProtQ8WXD0
Other data
LocusChr. 13 q12.3
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relaxin/insulin-like family peptide receptor 3
Identifiers
SymbolRXFP3
Alt. symbolsRLN3R1, SALPR, GPCR135
NCBI gene51289
HGNC24883
OMIM609445
RefSeqNM_016568
UniProtQ9NSD7
Other data
LocusChr. 5 p15.1-p14
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relaxin/insulin-like family peptide receptor 4
Identifiers
SymbolRXFP4
Alt. symbolsGPR100, GPCR142, RLN3R2
NCBI gene339403
HGNC14666
OMIM609043
RefSeqNM_181885
UniProtQ8TDU9
Other data
LocusChr. 1 q22
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Below is list of human relaxin receptors, their endogenous peptide hormones, and what downstream enzymes are activated or inhibited by the receptor.

receptor/gene ligands activates inhibits
RXFP1 relaxin 1, relaxin 2, relaxin 3 adenylate cyclase, protein kinase A, protein kinase C,

phosphatidylinositol 3-kinase, extracellular signal-regulated kinases (Erk1/2)
RXFP2 relaxin 1, relaxin 2, insulin-like 3 adenylate cyclase
RXFP3 relaxin 3 Erk1/2 signaling adenylate cyclase
RXFP4 relaxin 3, insulin-like 3 adenylate cyclase

See also

References
  1. Bathgate RA, Ivell R, Sanborn BM, Sherwood OD, Summers RJ (2006). "International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides". Pharmacol. Rev. 58 (1): 7–31. doi:10.1124/pr.58.1.9. PMID 16507880. S2CID 7466039.
  2. Halls ML, van der Westhuizen ET, Bathgate RA, Summers RJ (2007). "Relaxin family peptide receptors--former orphans reunite with their parent ligands to activate multiple signalling pathways". Br. J. Pharmacol. 150 (6): 677–91. doi:10.1038/sj.bjp.0707140. PMC 2013861. PMID 17293890.


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