Relaxin/insulin-like family peptide receptor 1

Relaxin/insulin-like family peptide receptor 1, also known as RXFP1, is a human G protein coupled receptor that is one of the relaxin receptors.[5] It is a rhodopsin-like GPCR which is unusual in this class as it contains a large extracellular binding and signalling domain.[6] Some reports suggest that RXFP1 forms homodimers,[7][8] however the most recent evidence indicates that relaxin binds a non-homodimer of RXFP1.[9][10]

RXFP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRXFP1, LGR7, RXFPR1, Relaxin/insulin-like family peptide receptor 1, relaxin/insulin like family peptide receptor 1, relaxin family peptide receptor 1
External IDsOMIM: 606654 MGI: 2682211 HomoloGene: 11007 GeneCards: RXFP1
Orthologs
SpeciesHumanMouse
Entrez

59350

381489

Ensembl

ENSG00000171509

ENSMUSG00000034009

UniProt

Q9HBX9

Q6R6I7

RefSeq (mRNA)

NM_212452

RefSeq (protein)

NP_997617

Location (UCSC)Chr 4: 158.32 – 158.65 MbChr 3: 79.55 – 79.65 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000171509 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000034009 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: RXFP1 relaxin/insulin-like family peptide receptor 1".
  6. Sethi A, Bruell S, Patil N, Hossain MA, Scott DJ, Petrie EJ, et al. (April 2016). "The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1". Nature Communications. 7 (1): 11344. doi:10.1038/ncomms11344. PMC 4837482. PMID 27088579.
  7. Svendsen AM, Zalesko A, Kønig J, Vrecl M, Heding A, Kristensen JB, et al. (December 2008). "Negative cooperativity in H2 relaxin binding to a dimeric relaxin family peptide receptor 1" (PDF). Molecular and Cellular Endocrinology. 296 (1–2): 10–7. doi:10.1016/j.mce.2008.07.014. PMID 18723073. S2CID 32739782.
  8. Kern A, Hubbard D, Amano A, Bryant-Greenwood GD (March 2008). "Cloning, expression, and functional characterization of relaxin receptor (leucine-rich repeat-containing g protein-coupled receptor 7) splice variants from human fetal membranes". Endocrinology. 149 (3): 1277–94. doi:10.1210/en.2007-1348. PMC 2275365. PMID 18079195.
  9. Hoare BL, Bruell S, Sethi A, Gooley PR, Lew MJ, Hossain MA, et al. (January 2019). "Multi-Component Mechanism of H2 Relaxin Binding to RXFP1 through NanoBRET Kinetic Analysis". iScience. 11: 93–113. doi:10.1016/j.isci.2018.12.004. PMC 6309025. PMID 30594862.
  10. Hoare BL, Kocan M, Bruell S, Scott DJ, Bathgate RA (August 2019). "Using the novel HiBiT tag to label cell surface relaxin receptors for BRET proximity analysis". Pharmacology Research & Perspectives. 7 (4): e00513. doi:10.1002/prp2.513. PMC 6667744. PMID 31384473.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.