Hydroxycarboxylic acid receptor 3

Hydroxycarboxylic acid receptor 3 (HCA3), also known as niacin receptor 2 (NIACR2) and GPR109B,[3] is a protein which in humans is encoded by the HCAR3 gene.[4][5] HCA3, like the other hydroxycarboxylic acid receptors HCA1 and HCA2, is a Gi/o-coupled G protein-coupled receptor (GPCR).[6][7] The primary endogenous agonists of HCA3 are 3-hydroxyoctanoic acid and kynurenic acid.[6][7][8] HCA3 is also a low-affinity biomolecular target for niacin (aka nicotinic acid).[9]

HCAR3
Identifiers
AliasesHCAR3, GPR109B, HCA3, HM74, PUMAG, Puma-g, Niacin receptor 2, hydroxycarboxylic acid receptor 3
External IDsOMIM: 606039 HomoloGene: 130547 GeneCards: HCAR3
Orthologs
SpeciesHumanMouse
Entrez

8843

n/a

Ensembl

ENSG00000255398

n/a

UniProt

P49019

n/a

RefSeq (mRNA)

NM_006018

n/a

RefSeq (protein)

NP_006009

n/a

Location (UCSC)Chr 12: 122.71 – 122.72 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

References

  1. GRCh38: Ensembl release 89: ENSG00000255398 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. Offermanns S, Colletti SL, Lovenberg TW, Semple G, Wise A, IJzerman AP (June 2011). "International Union of Basic and Clinical Pharmacology. LXXXII: Nomenclature and Classification of Hydroxy-carboxylic Acid Receptors (GPR81, GPR109A, and GPR109B)". Pharmacological Reviews. 63 (2): 269–90. doi:10.1124/pr.110.003301. PMID 21454438.
  4. "Entrez Gene: GPR109B G protein-coupled receptor 109B".
  5. Nomura H, Nielsen BW, Matsushima K (October 1993). "Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors". International Immunology. 5 (10): 1239–49. doi:10.1093/intimm/5.10.1239. PMID 7505609.
  6. Offermanns S, Colletti SL, Lovenberg TW, Semple G, Wise A, IJzerman AP (June 2011). "International Union of Basic and Clinical Pharmacology. LXXXII: Nomenclature and Classification of Hydroxy-carboxylic Acid Receptors (GPR81, GPR109A, and GPR109B)". Pharmacological Reviews. 63 (2): 269–90. doi:10.1124/pr.110.003301. PMID 21454438.
  7. S Offermanns, SL Colletti, AP IJzerman, TW Lovenberg, G Semple, A Wise, MG Waters. "Hydroxycarboxylic acid receptors". IUPHAR/BPS Guide to Pharmacology. International Union of Basic and Clinical Pharmacology. Retrieved 13 July 2018.{{cite web}}: CS1 maint: multiple names: authors list (link)
  8. Kapolka, NJ; Taghon, GJ; Rowe, JB; Morgan, WM; Enten, JF; Lambert, NA; Isom, DG (9 June 2020). "DCyFIR: a high-throughput CRISPR platform for multiplexed G protein-coupled receptor profiling and ligand discovery". Proceedings of the National Academy of Sciences of the United States of America. 117 (23): 13117–13126. Bibcode:2020PNAS..11713117K. doi:10.1073/pnas.2000430117. PMC 7293659. PMID 32434907.
  9. Peters, A; Krumbholz, P; Jäger, E; Heintz-Buschart, A; Çakir, MV; Rothemund, S; Gaudl, A; Ceglarek, U; Schöneberg, T; Stäubert, C (May 2019). "Metabolites of lactic acid bacteria present in fermented foods are highly potent agonists of human hydroxycarboxylic acid receptor 3". PLOS Genetics. 15 (5): e1008145. doi:10.1371/journal.pgen.1008145. PMC 6532841. PMID 31120900.

Further reading

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