P2RY11

P2Y purinoceptor 11 is a protein that in humans is encoded by the P2RY11 gene.[3][4]

P2RY11
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2B6S
Identifiers
Aliases	P2RY11, P2Y11, purinergic receptor P2Y11
External IDs	OMIM: 602697 HomoloGene: 130446 GeneCards: P2RY11
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.2 Start 10,111,693 bp[1] End 10,115,372 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube skin of abdomen putamen spleen nucleus accumbens caudate nucleus hippocampus proper left lobe of thyroid gland dorsolateral prefrontal cortex Brodmann area 9 n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity G protein-coupled purinergic nucleotide receptor activity signal transducer activity G protein-coupled ATP receptor activity neurotransmitter receptor activity signaling receptor activity Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane intracellular anatomical structure Biological process defense response neuronal signal transduction activation of adenylate cyclase activity G protein-coupled purinergic nucleotide receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway cellular response to ATP calcium-mediated signaling signal transduction G protein-coupled adenosine receptor signaling pathway G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5032 n/a Ensembl ENSG00000244165 n/a UniProt Q96G91 n/a RefSeq (mRNA) NM_002566 n/a RefSeq (protein) NP_002557 n/a Location (UCSC) Chr 19: 10.11 – 10.12 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

The product of this gene, P2Y₁₁, belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is coupled to the stimulation of the phosphoinositide and adenylyl cyclase pathways and behaves as a selective purinoceptor. Naturally occurring read-through transcripts, resulting from intergenic splicing between this gene and an immediately upstream gene (PPAN, encoding peter pan homolog), have been found. The PPAN-P2RY11 read-through mRNA is ubiquitously expressed and encodes a fusion protein that shares identity with each individual gene product.[4]