LPAR4

LPAR4
Identifiers
Aliases	LPAR4, GPR23, LPA4, P2RY9, P2Y5-LIKE, P2Y9, lysophosphatidic acid receptor 4
External IDs	OMIM: 300086 MGI: 1925384 HomoloGene: 3871 GeneCards: LPAR4
Gene location (Human)
Chr.	X chromosome (human)[1]
End	78,758,714 bp[1]
Gene location (Mouse)
Chr.	X chromosome (mouse)[2]
End	105,977,506 bp[2]
RNA expression pattern
	Top expressed in
	sural nerve; ; tibia; ; ganglionic eminence; ; Achilles tendon; ; monocyte; ; optic nerve; ; gastric mucosa; ; gallbladder; ; corpus callosum; ; smooth muscle tissue;
	Top expressed in
	dermis; ; pituitary stalk; ; primitive streak; ; trigeminal ganglion; ; tongue; ; left lung lobe; ; rib; ; vas deferens; ; abdominal wall; ; hand;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	lysophosphatidic acid binding; signal transducer activity; lipid binding; G protein-coupled receptor activity; lysophosphatidic acid receptor activity;
Cellular component	integral component of membrane; membrane; integral component of plasma membrane; plasma membrane; nuclear body; intracellular membrane-bounded organelle;
Biological process	signal transduction; positive regulation of Rho protein signal transduction; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	2846
	78134
	ENSG00000147145
	ENSMUSG00000049929
	Q99677
	Q8BLG2
	NM_001278000; NM_005296
	NM_175271
	NP_001264929; NP_005287
	NP_780480
	Wikidata
View/Edit Human	View/Edit Mouse

Lysophosphatidic acid receptor 4 also known as LPA₄ is a protein that in humans is encoded by the LPAR4 gene.[5][6][7] LPA₄ is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).[8]

References

GRCh38: Ensembl release 89: ENSG00000147145 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000049929 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: GPR23 G protein-coupled receptor 23".
Janssens R, Boeynaems JM, Godart M, Communi D (July 1997). "Cloning of a human heptahelical receptor closely related to the P2Y5 receptor". Biochem. Biophys. Res. Commun. 236 (1): 106–12. doi:10.1006/bbrc.1997.6895. PMID 9223435.
O'Dowd BF, Nguyen T, Jung BP, Marchese A, Cheng R, Heng HH, Kolakowski LF, Lynch KR, George SR (March 1997). "Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes". Gene. 187 (1): 75–81. doi:10.1016/S0378-1119(96)00722-6. PMID 9073069.
Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J (January 2010). "LPA Receptors: Subtypes and Biological Actions". Annual Review of Pharmacology and Toxicology. 50 (1): 157–186. doi:10.1146/annurev.pharmtox.010909.105753. PMID 20055701.

Adrian K, Bernhard MK, Breitinger HG, Ogilvie A (2000). "Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells". Biochim. Biophys. Acta. 1492 (1): 127–38. doi:10.1016/S0167-4781(00)00094-4. PMID 11004484.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Noguchi K, Ishii S, Shimizu T (2003). "Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family". J. Biol. Chem. 278 (28): 25600–6. doi:10.1074/jbc.M302648200. PMID 12724320.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000147145 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000049929 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: GPR23 G protein-coupled receptor 23".

[pmid9223435-6] Janssens R, Boeynaems JM, Godart M, Communi D (July 1997). "Cloning of a human heptahelical receptor closely related to the P2Y5 receptor". Biochem. Biophys. Res. Commun. 236 (1): 106–12. doi:10.1006/bbrc.1997.6895. PMID 9223435.

[pmid9073069-7] O'Dowd BF, Nguyen T, Jung BP, Marchese A, Cheng R, Heng HH, Kolakowski LF, Lynch KR, George SR (March 1997). "Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes". Gene. 187 (1): 75–81. doi:10.1016/S0378-1119(96)00722-6. PMID 9073069.

[Choi_2010-8] Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J (January 2010). "LPA Receptors: Subtypes and Biological Actions". Annual Review of Pharmacology and Toxicology. 50 (1): 157–186. doi:10.1146/annurev.pharmtox.010909.105753. PMID 20055701.

LPAR4

See also

References

Further reading