Hypocretin (orexin) receptor 1

Orexin receptor type 1 (Ox1R or OX1), also known as hypocretin receptor type 1 (HcrtR1), is a protein that in humans is encoded by the HCRTR1 gene.[5]

HCRTR1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHCRTR1, OX1R, Hypocretin (orexin) receptor 1, hypocretin receptor 1, ORXR1, OXR1
External IDsOMIM: 602392 MGI: 2385650 HomoloGene: 37492 GeneCards: HCRTR1
Orthologs
SpeciesHumanMouse
Entrez

3061

230777

Ensembl

ENSG00000121764

ENSMUSG00000028778

UniProt

O43613

P58307

RefSeq (mRNA)

NM_001525

NM_001163027
NM_198959
NM_001305392
NM_001357258

RefSeq (protein)

NP_001516

NP_001156499
NP_001292321
NP_945197
NP_001344187

Location (UCSC)Chr 1: 31.62 – 31.63 MbChr 4: 130.02 – 130.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The orexin 1 receptor (OX1), is a G-protein coupled receptor that is heavily expressed in projections from the lateral hypothalamus and is involved in the regulation of feeding behaviour. OX1 selectively binds the orexin-A neuropeptide. It shares 64% identity with OX2.[5]

Ligands

Agonists

Antagonists

See also

References

  • "Orexin Receptors: OX1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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