MAS1 oncogene
The MAS1 oncogene (MAS receptor) is a G protein-coupled receptor[1][2] which binds the angiotensin II metabolite angiotensin (1-7).[3][4] The MAS1 receptor, when activated by binding angiotensin-(1-7), opposes many of the effects of the angiotensin II receptor. Hence, MAS1 receptor agonists have similar therapeutic effects to angiotensin II receptor antagonists, including lowering of blood pressure.[5]
| MAS1 oncogene | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | MAS1 | ||||||
| NCBI gene | 4142 | ||||||
| HGNC | 6899 | ||||||
| OMIM | 165180 | ||||||
| RefSeq | NM_002377 | ||||||
| UniProt | P04201 | ||||||
| Other data | |||||||
| Locus | Chr. 6 q24-q27 | ||||||
| |||||||
| MAS1 oncogene-like | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | MAS1L | ||||||
| NCBI gene | 116511 | ||||||
| HGNC | 13961 | ||||||
| OMIM | 607235 | ||||||
| RefSeq | NM_052967 | ||||||
| UniProt | P35410 | ||||||
| Other data | |||||||
| Locus | Chr. 6 p21 | ||||||
| |||||||
References
- Nunes-Silva A, Rocha GC, Magalhaes DM, Vaz LN, Salviano de Faria MH, Simoes e Silva AC (November 2017). "Physical Exercise and ACE2-Angiotensin-(1-7)-Mas Receptor Axis of the Renin Angiotensin System". Protein and Peptide Letters. Bentham Science Publishers Ltd. 24 (9): 809–816. doi:10.2174/0929866524666170728151401. PMID 28758593.
(2) a counter-regulatory or vasodilator pathway comprising angiotensin-converting enzyme 2 (ACE2), Angiotensin-(1-7) [Ang-(1-7)] and Mas receptor, which is involved in vasodilation, antiproliferation, anti-hypertrophy, cardioprotective and renoprotective actions.
- Young D, Waitches G, Birchmeier C, Fasano O, Wigler M (June 1986). "Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains". Cell. 45 (5): 711–9. doi:10.1016/0092-8674(86)90785-3. PMID 3708691. S2CID 29886272.
- Santos RA, Simoes e Silva AC, Maric C, Silva DM, Machado RP, de Buhr I, et al. (July 2003). "Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas". Proceedings of the National Academy of Sciences of the United States of America. 100 (14): 8258–63. Bibcode:2003PNAS..100.8258S. doi:10.1073/pnas.1432869100. PMC 166216. PMID 12829792.
- Santos RA, Ferreira AJ (March 2007). "Angiotensin-(1-7) and the renin-angiotensin system". Current Opinion in Nephrology and Hypertension. 16 (2): 122–8. doi:10.1097/MNH.0b013e328031f362. PMID 17293687. S2CID 32812104.
- Santos RA, Ferreira AJ (2006). "Pharmacological effects of AVE 0991, a nonpeptide angiotensin-(1-7) receptor agonist". Cardiovascular Drug Reviews. 24 (3–4): 239–46. doi:10.1111/j.1527-3466.2006.00239.x. PMID 17214600.
External links
- IUPHAR GPCR Database - MAS1
- IUPHAR GPCR Database - MAS1L
- proto-oncogene+proteins+c-mas-1 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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