Galanin receptor 1

Galanin receptor 1 (GAL1) is a G-protein coupled receptor encoded by the GALR1 gene.[5]

GALR1
Identifiers
AliasesGALR1, GALNR, GALNR1, Galanin receptor 1
External IDsOMIM: 600377 MGI: 1096364 HomoloGene: 74396 GeneCards: GALR1
Orthologs
SpeciesHumanMouse
Entrez

2587

14427

Ensembl

ENSG00000166573

ENSMUSG00000024553

UniProt

P47211

P56479

RefSeq (mRNA)

NM_001480

NM_008082

RefSeq (protein)

NP_001471

NP_032108

Location (UCSC)Chr 18: 77.25 – 77.28 MbChr 18: 82.41 – 82.42 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-trans membrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the GI/GO family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart.[5]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000166573 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000024553 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: GALR1 galanin receptor 1".

Further reading

  • "Galanin Receptors: GAL1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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