Clobetasol

Clobetasol (brand name Dermovat) is a synthetic glucocorticoid corticosteroid which is marketed in Denmark.[1][2] A propionate ester of clobetasol, clobetasol propionate, has also been marketed, and is far more widely used in comparison.[1][2]

Not to be confused with Clobetasol propionate.
Clobetasol
Clinical data
Trade namesDermovat
Other names9α-Fluoro-11β,17α-dihydroxy-16β-methyl-21-chloropregna-1,4-diene-3,20-dione
Drug classCorticosteroid; Glucocorticoid
Identifiers
IUPAC name
  • (8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-Chloroacetyl)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
ECHA InfoCard100.042.379
Chemical and physical data
FormulaC22H28ClFO4
Molar mass410.91 g·mol−1
3D model (JSmol)
SMILES
  • C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CCl)O)C)O)F)C
InChI
  • InChI=1S/C22H28ClFO4/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,24)17(26)10-20(16,3)22(12,28)18(27)11-23/h6-7,9,12,15-17,26,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,17-,19-,20-,21-,22-/m0/s1
  • Key:FCSHDIVRCWTZOX-DVTGEIKXSA-N

References
  1. Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 292–. doi:10.1007/978-1-4757-2085-3. ISBN 978-1-4757-2085-3.
  2. Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 252–. ISBN 978-3-88763-075-1.



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