Formocortal

Formocortal (INN), also known as fluoroformylone, is a corticosteroid used in dermatology[1] and ophthalmology.[2]

Formocortal
Clinical data
Other names3-(2-chloroethoxy)-6-formyl-9α-fluoropregna-3,5-diene-11β,16α,17,21-tetrol-20-one 21-acetate
ATC code
Identifiers
IUPAC name
  • 2-[(1S,2S,4R,8S,9S,11S,12R,13S)-16-(2-chloroethoxy)-12-fluoro-19-formyl-11-hydroxy-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-16,18-dien-8-yl]-2-oxoethyl acetate
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
Chemical and physical data
FormulaC29H38ClFO8
Molar mass569.06 g·mol−1
3D model (JSmol)
SMILES
  • CC(=O)OCC(=O)[C@@]12[C@@H](C[C@@H]3[C@@]1(C[C@@H]([C@]4([C@H]3CC(=C5[C@@]4(CCC(=C5)OCCCl)C)C=O)F)O)C)OC(O2)(C)C
InChI
  • InChI=1S/C29H38ClFO8/c1-16(33)37-15-23(35)29-24(38-25(2,3)39-29)12-20-21-10-17(14-32)19-11-18(36-9-8-30)6-7-26(19,4)28(21,31)22(34)13-27(20,29)5/h11,14,20-22,24,34H,6-10,12-13,15H2,1-5H3/t20-,21-,22-,24+,26-,27-,28-,29+/m0/s1 N
  • Key:QNXUUBBKHBYRFW-QWAPGEGQSA-N N
 NY (what is this?)  (verify)

It was introduced in around 1970[1] and is not known to be marketed as of 2021.

See also

References
  1. Aliperta, G.; Lattaro, R. (1971). "On the topical use of a new steroid, formocortal, in the treatment of phlebodermitis and in cutaneous auto- and homo-grafts". Minerva Cardioangiologica. 19 (11): 620–624. PMID 4942789.
  2. Marchese A, Bozzolasco M, Gualco L, Schito GC, Debbia EA (2001). "Evaluation of spontaneous contamination of ocular medications". Chemotherapy. 47 (4): 304–8. doi:10.1159/000048538. PMID 11399868. S2CID 33870589.
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