Fluocinolone

Fluocinolone is a synthetic glucocorticoid corticosteroid which was never marketed.[1][2] The acetonide cyclic ketal of fluocinolone, fluocinolone acetonide, in contrast, has been marketed.[1][2]

Not to be confused with Fluocinolone acetonide.
Fluocinolone
Clinical data
Other names6α-Fluorotriamcinolone; 6α,9α-Difluoro-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione
Drug classCorticosteroid; Glucocorticoid
Identifiers
IUPAC name
  • (6S,8S,9R,10S,11S,13S,14S,16R,17S)-6,9-Difluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
CAS Number
PubChem CID
ChemSpider
UNII
ECHA InfoCard100.011.239
Chemical and physical data
FormulaC21H26F2O6
Molar mass412.430 g·mol−1
3D model (JSmol)
SMILES
  • C[C@]12C[C@@H]([C@]3([C@H]([C@@H]1C[C@H]([C@@]2(C(=O)CO)O)O)C[C@@H](C4=CC(=O)C=C[C@@]43C)F)F)O
InChI
  • InChI=1S/C21H26F2O6/c1-18-4-3-10(25)5-13(18)14(22)6-12-11-7-15(26)21(29,17(28)9-24)19(11,2)8-16(27)20(12,18)23/h3-5,11-12,14-16,24,26-27,29H,6-9H2,1-2H3/t11-,12-,14-,15+,16-,18-,19-,20-,21-/m0/s1
  • Key:UUOUOERPONYGOS-CLCRDYEYSA-N

References
  1. Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 282–. ISBN 978-1-4757-2085-3.
  2. Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 455–456. ISBN 978-3-88763-075-1.



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