Methylprednisolone aceponate

Methylprednisolone aceponate, or methylprednisolone acetate propionate, sold under the brand names Advantan and Avancort, is a glucocorticoid and a corticosteroid ester—specifically the C17α propionate and C21 acetate diester of methylprednisolone.[1][2][3]

Methylprednisolone aceponate
Clinical data
Trade namesAdvantan, Avancort
Other namesMethylprednisolone 17α-propionate 21-acetate; ZK-91588
AHFS/Drugs.comConsumer Drug Information
ATC code
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.184.880
Chemical and physical data
FormulaC27H36O7
Molar mass472.578 g·mol−1
3D model (JSmol)
SMILES
  • CCC(=O)O[C@@]1(CC[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2C[C@@H](C4=CC(=O)C=C[C@]34C)C)O)C)C(=O)COC(=O)C
InChI
  • InChI=1S/C27H36O7/c1-6-23(32)34-27(22(31)14-33-16(3)28)10-8-19-18-11-15(2)20-12-17(29)7-9-25(20,4)24(18)21(30)13-26(19,27)5/h7,9,12,15,18-19,21,24,30H,6,8,10-11,13-14H2,1-5H3/t15-,18-,19-,21-,24+,25-,26-,27-/m0/s1 N
  • Key:DALKLAYLIPSCQL-YPYQNWSCSA-N N
 NY (what is this?)  (verify)

See also

References
  1. J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 811–. ISBN 978-1-4757-2085-3.
  2. Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 675–. ISBN 978-3-88763-075-1.
  3. Bieber T, Vick K, Fölster-Holst R, et al. (February 2007). "Efficacy and safety of methylprednisolone aceponate ointment 0.1% compared to tacrolimus 0.03% in children and adolescents with an acute flare of severe atopic dermatitis". Allergy. 62 (2): 184–9. doi:10.1111/j.1398-9995.2006.01269.x. PMID 17298428.



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