Diflorasone diacetate

Diflorasone diacetate is a topical steroid that comes in the form of a cream. It is manufactured by E. Fougera & Co. and is used as an anti-inflammatory and anti-itching agent, like other topical corticosteroids. It is prescribed for psoriasis[1] and atopic dermatitis, among other conditions. With respect to potency, it is regarded as a Class I corticosteroid [of classes I – VII] in the United States.[2]

Diflorasone diacetate
Clinical data
Trade namesPsorcon
AHFS/Drugs.comMonograph
MedlinePlusa602019
License data
Routes of
administration		Topical
ATC code
Legal status
Legal status
Identifiers
IUPAC name
  • [17-(2-Acetyloxyacetyl)- 6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16- octahydrocyclopenta[a]phenanthren-17-yl] acetate
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.046.872
Chemical and physical data
FormulaC26H32F2O7
Molar mass494.532 g·mol−1
InChI
  • InChI=1S/C26H32F2O7/c1-13-8-17-18-10-20(27)19-9-16(31)6-7-23(19,4)25(18,28)21(32)11-24(17,5)26(13,35-15(3)30)22(33)12-34-14(2)29/h6-7,9,13,17-18,20-21,32H,8,10-12H2,1-5H3/t13-,17-,18-,20-,21-,23-,24-,25-,26-/m0/s1 Y
  • Key:BOBLHFUVNSFZPJ-JOYXJVLSSA-N Y
 NY (what is this?)  (verify)

No long-term animal studies have been done to determine whether diflorasone diacetate could have carcinogenic properties.

Little data is available regarding whether diflorasone diacetate would be present in great enough quantities to cause harm to an infant.[3]

References
  1. Shupack JL, Jondreau L, Kenny C, Stiller MJ (1993). "Diflorasone diacetate ointment 0.05% versus betamethasone dipropionate ointment 0.05% in moderate-severe plaque-type psoriasis". Dermatology. 186 (2): 129–32. doi:10.1159/000247323. PMID 8428041.
  2. "Topical Steroids Potency Chart". psoriasis.org.
  3. "Diflorasone topical". Drugs.com.


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