Aceclidine

Aceclidine
Skeletal formula of aceclidine
Ball-and-stick model of the aceclidine molecule
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration		Topical (ophthalmic solution)
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Metabolismdeacetylation?
Identifiers
IUPAC name
  • 1-Azabicyclo[2.2.2]oct-3-yl acetate; 3-Quinuclidinyl Acetate
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.011.431
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Chemical and physical data
FormulaC9H15NO2
Molar mass169.224 g·mol−1
3D model (JSmol)
SMILES
  • O=C(OC2C1CCN(CC1)C2)C
InChI
  • InChI=1S/C9H15NO2/c1-7(11)12-9-6-10-4-2-8(9)3-5-10/h8-9H,2-6H2,1H3 checkY
  • Key:WRJPSSPFHGNBMG-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Aceclidine (Glaucostat, Glaunorm, Glaudin) is a parasympathomimetic miotic agent used in the treatment of narrow angle glaucoma. It decreases intraocular pressure.

Adverse effects

Side effects of aceclidine include increased salivation and bradycardia (in excessive doses).

Mechanism of action

Aceclidine acts as a muscarinic acetylcholine receptor agonist.[1]

See also

References

  1. ↑ Shannon HE, Hart JC, Bymaster FP, et al. (August 1999). "Muscarinic receptor agonists, like dopamine receptor antagonist antipsychotics, inhibit conditioned avoidance response in rats". J. Pharmacol. Exp. Ther. 290 (2): 901–7. PMID 10411607.
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