Terodiline
Clinical data | |
---|---|
ATC code | |
Identifiers | |
IUPAC name
| |
CAS Number |
|
PubChem CID | |
ChemSpider |
|
UNII | |
ChEMBL | |
CompTox Dashboard (EPA) | |
Chemical and physical data | |
Formula | C20H27N |
Molar mass | 281.443 g·mol−1 |
3D model (JSmol) | |
SMILES
| |
InChI
| |
(verify) |
Terodiline is a drug used in urology as an antispasmodic.
It relaxes the smooth muscle and used to reduce bladder tone in treatment of urinary frequency and incontinence. Muscle relaxation caused by terodiline, is probably due to its anticholinergic and calcium antagonist activity.
However, it also blocks IKr (Kv11.1) channels (see hERG gene) so can pose a risk for torsades de pointes. This cardiotoxicity is concentration dependent.[1]
References
- ↑ Thomas SH, Higham PD, Hartigan-Go K, Kamali F, Wood P, Campbell RW, Ford GA (1995). "Concentration dependent cardiotoxicity of terodiline in patients treated for urinary incontinence". Br Heart J. 74 (1): 53–6. doi:10.1136/hrt.74.1.53. PMC 483946. PMID 7662454.
Urologicals, including antispasmodics (G04B) | |
---|---|
Acidifiers |
|
Urinary antispasmodics (primarily antimuscarinics) | |
Other urologicals |
|
mAChRs |
| ||||
---|---|---|---|---|---|
Precursors (and prodrugs) |
| ||||
See also: Receptor/signaling modulators • Nicotinic acetylcholine receptor modulators • Acetylcholine metabolism/transport modulators |
This article is issued from Offline. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.