Potassium channel opener

A potassium channel opener is a type of drug which facilitates ion transmission through potassium channels.

Examples

Some examples include:

Class Subclasses Activators
Calcium-activated

6T & 1P

Inwardly rectifying

2T & 1P

  • ROMK (Kir1.1)
  • none
  • GPCR regulated (Kir3.x)
  • GPCR agonists
  • ML-297 (VU0456810)
  • ATP-sensitive (Kir6.x)
Tandem pore domain

4T & 2P

Voltage-gated

6T & 1P

  • hERG (Kv11.1)
  • KvLQT1 (Kv7.1)

See also

References

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  9. 1 2 Fink M, Lesage F, Duprat F, Heurteaux C, Reyes R, Fosset M, Lazdunski M (Jun 1998). "A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids". The EMBO Journal. 17 (12): 3297–308. doi:10.1093/emboj/17.12.3297. PMC 1170668. PMID 9628867.
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  16. Rogawski MA, Bazil CW (Jul 2008). "New molecular targets for antiepileptic drugs: alpha(2)delta, SV2A, and K(v)7/KCNQ/M potassium channels". Current Neurology and Neuroscience Reports. 8 (4): 345–52. doi:10.1007/s11910-008-0053-7. PMC 2587091. PMID 18590620.


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