Serdexmethylphenidate/dexmethylphenidate

Not to be confused with serdexmethylphenidate.
Serdexmethylphenidate/dexmethylphenidate
Combination of
SerdexmethylphenidateProdrug of dexmethylphenidate
DexmethylphenidateCatecholamine reuptake inhibitor
Names
Trade namesAzstarys
Other namesKP415
Clinical data
Main usesAttention deficit hyperactivity disorder (ADHD)[1]
Side effectsDecreased appetite, trouble sleeping, nausea, abdominal pain, anxiety, irritability, fast heart rate, increased blood pressure[1]
InteractionsMonoamine oxidase inhibitors[1]
WHO AWaReUnlinkedWikibase error: ⧼unlinkedwikibase-error-statements-entity-not-set⧽
Dependence riskHigh[1]
Routes of
use		By mouth
External links
AHFS/Drugs.comMonograph
Legal
License data
Legal status

Serdexmethylphenidate/dexmethylphenidate, sold under the brand name Azstarys, is a combination medication used to treat attention deficit hyperactivity disorder (ADHD).[1] It is used in people at least six years old.[1] It is taken by mouth.[1]

Common side effects include decreased appetite, trouble sleeping, nausea, abdominal pain, anxiety, irritability, fast heart rate, and increased blood pressure.[1] Other side effects may include psychosis, priapism, Raynaud, and heart problems.[1] It has a high risk of abuse.[1] Safety in pregnancy is unclear.[1] It contains serdexmethylphenidate and dexmethylphenidate, which act as central nervous system stimulants.[1]

The combination was approved for medical use in the United States in 2021.[1] It is not approved in Europe or the United Kingdom as of 2022.[2] In the United States it costs about 400 USD per month as of 2022.[3] In the United States it is a Schedule II controlled substance.[1]

Medical uses

Dosage

It is generally taken at a dose of 26.1/5.2 mg to 52.3/10.4mg once per day.[1]

References

  1. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 "Azstarys- serdexmethylphenidate and dexmethylphenidate capsule". DailyMed. Archived from the original on 13 July 2021. Retrieved 13 July 2021.
  2. ↑ "Serdexmethylphenidate + dexmethylphenidate". SPS - Specialist Pharmacy Service. 30 November 2018. Retrieved 31 October 2022.{{cite web}}: CS1 maint: url-status (link)
  3. ↑ "Azstarys". Archived from the original on 31 October 2022. Retrieved 31 October 2022.
Identifiers:
  • "Serdexmethylphenidate". Drug Information Portal. U.S. National Library of Medicine. Archived from the original on 7 October 2021. Retrieved 30 July 2022.
  • "Dexmethylphenidate". Drug Information Portal. U.S. National Library of Medicine. Archived from the original on 7 October 2021. Retrieved 30 July 2022.



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