Progesterone/hydroxyprogesterone heptanoate/α-tocopherol palmitate
| Combination of | |
|---|---|
| Progesterone | Progestogen |
| Hydroxyprogesterone heptanoate | Progestogen |
| α-Tocopherol palmitate | Vitamin E |
| Clinical data | |
| Trade names | Tocogestan |
| Other names | P4/OHPH/VE; P4/OHPH/α-TP |
| Routes of administration | Intramuscular injection |
Progesterone/hydroxyprogesterone heptanoate/α-tocopherol palmitate (P4/OHPH/VE), sold under the brand name Tocogestan, is a combination medication of progesterone (P4), a short-acting progestogen, hydroxyprogesterone heptanoate (OHPH), a long-acting progestogen, and α-tocopherol palmitate, a prodrug of α-tocopherol and form of vitamin E, which was previously used in France to support pregnancy in women but is no longer available.[1][2][3][4] It contained 50 mg P4, 200 mg OHPH, and 250 mg in 2 mL oil solution, was provided in the form of 2 mL ampoules, and was administered by intramuscular injection.[1][4]
See also
References
- 1 2 https://www.ansm.sante.fr/searchengine/detail/(cis)/63964026
- ↑ Laurent, M. (1996). Progestatifs et anti-androgènes. CNGOF Collège national des gynécologues et obstétriciens français. Mises à jour en Gynécologie et Obstétrique. Paris: Vigot, 157-192. "d. Voie intramusculaire (Tocogestan®) : c’est une solution huileuse comprenant un mélange de progestérone naturelle et d’heptanoate de 17-OH-progestérone ; ce dernier lui confère une durée d’action prolongée permettant d’espacer les injections. [...] L’estérification par l’acide caproïque (Progestérone retard®) ou heptanoïque (Tocogestan®) donne naissance à des composés d’action prolongée (permettant d’espacer les injections) dont le profil biologique est proche de l’hormone naturelle. Utilisés essentiellement pendant la grossesse, ils sont actuellement délaissés au profit de la progestérone micronisée."
- ↑ Claude Sureau (1986). Control and Management of Parturition. John Libbey Eurotext. pp. 235–. ISBN 978-0-86196-096-5.
[...] … quotidienne parait suffisante. -hydroxyprogestérone caproate (progestérone retard pharlon) -hydroxyprogestérone heptanoate+ vitamine E (tocogestan) -progestérone+ vitamine E (vitamine E/progestérone fournier). L'inconvénient … [...]
- 1 2 Sasco AJ, Gendre I, Verbier-Naneix C, Soulier JL, Raffi F, Satgé D, Robert E (1998). "Neonatal neuroblastoma and in utero exposure to progestagens". International Journal of Risk and Safety in Medicine. 11 (2): 121–128.
This article is issued from Offline. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.