SFRP2

SFRP2
المعرفات
الأسماء المستعارة	SFRP2, FRP-2, SARP1, SDF-5, secreted frizzled related protein 2
معرفات خارجية	الوراثة المندلية البشرية عبر الإنترنت 604157 MGI: MGI:108078 HomoloGene: 56438 GeneCards: 6423
علم الوجود الجيني
الوظيفة الجزيئية	• fibronectin binding; • receptor ligand activity; • endopeptidase activator activity; • integrin binding; • ‏GO:0010577 enzyme activator activity; • G protein-coupled receptor activity; • Wnt-protein binding; • Wnt-activated receptor activity;
المكونات الخلوية	• ‏GO:0005578 نسيج خارج الخلية; • منطقة خارج الخلية; • خارج خلوي; • مكون تكاملي للغشاء; • collagen-containing extracellular matrix;
العمليات الحيوية	• cellular response to extracellular stimulus; • positive regulation of endopeptidase activity; • Wnt signaling pathway involved in somitogenesis; • تكون الجسيدات; • تمايز خلوي; • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; • male gonad development; • regulation of establishment of planar polarity; • response to nutrient; • collagen fibril organization; • convergent extension involved in axis elongation; • development of primary male sexual characteristics; • positive regulation of canonical Wnt signaling pathway; • negative regulation of mesodermal cell fate specification; • cellular response to X-ray; • cell-cell signaling; • negative regulation of Wnt signaling pathway; • bone morphogenesis; • hematopoietic stem cell proliferation; • chondrocyte development; • embryonic digit morphogenesis; • outflow tract morphogenesis; • cardiac left ventricle morphogenesis; • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; • بروتين دبيلو.أن.تي; • negative regulation of gene expression; • sclerotome development; • positive regulation of peptidyl-serine phosphorylation; • positive regulation of angiogenesis; • planar cell polarity pathway involved in neural tube closure; • negative regulation of BMP signaling pathway; • نمو متعدد الخلايا; • negative regulation of cardiac muscle cell apoptotic process; • regulation of apoptotic process; • positive regulation of cell growth; • neural tube closure; • negative regulation of peptidyl-tyrosine phosphorylation; • negative regulation of cell migration; • positive regulation of osteoblast differentiation; • regulation of Wnt signaling pathway; • تَكوّن الغُضروف; • regulation of cell population proliferation; • regulation of stem cell division; • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; • negative regulation of cell growth; • neural tube development; • ضبط زيادي للتكاثر الخلوي; • negative regulation of epithelial cell proliferation; • positive regulation of apoptotic process; • branching involved in blood vessel morphogenesis; • post-anal tail morphogenesis; • negative regulation of dermatome development; • negative regulation of planar cell polarity pathway involved in axis elongation; • positive regulation of cell adhesion mediated by integrin; • ‏GO:0045996 negative regulation of transcription, DNA-templated; • negative regulation of JUN kinase activity; • positive regulation of fat cell differentiation; • negative regulation of epithelial to mesenchymal transition; • negative regulation of cell population proliferation; • ‏GO:0003257، ‏GO:0010735، ‏GO:1901228، ‏GO:1900622، ‏GO:1904488 ضبط زيادي للنسخ انطلاقا من محفز بوليميراز الرنا الثاني; • digestive tract morphogenesis; • نقل شاردة الكالسيوم; • ‏GO:0097285 استماتة; • negative regulation of canonical Wnt signaling pathway; • regulation of midbrain dopaminergic neuron differentiation; • regulation of neuron projection development; • G protein-coupled receptor signaling pathway; • non-canonical Wnt signaling pathway; • regulation of signaling receptor activity; • canonical Wnt signaling pathway;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	; ;
	المزيد من بيانات التعبير المرجعية
أورثولوج
	Q96HF1
	P97299
	NM_003013
	NM_009144
	NP_003004
	NP_033170
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

SFRP2‏ (Secreted frizzled related protein 2) هوَ بروتين يُشَفر بواسطة جين SFRP2 في الإنسان.[1][2]

المراجع

"Entrez Gene: SFRP2 secreted frizzled-related protein 2"، مؤرشف من الأصل في 5 ديسمبر 2010.
"SARPs: A family of secreted apoptosis-related proteins"، Proc Natl Acad Sci U S A، 94 (25): 13636–41، يناير 1998، doi:10.1073/pnas.94.25.13636، PMC 28358، PMID 9391078.

قراءة متعمقة

"A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors"، Proc. Natl. Acad. Sci. U.S.A.، 94 (7): 2859–63، 1997، doi:10.1073/pnas.94.7.2859، PMC 20287، PMID 9096311.
"Tissue restricted expression of two human Frzbs in preadipocytes and pancreas"، Biochem. Biophys. Res. Commun.، 247 (2): 287–93، 1998، doi:10.1006/bbrc.1998.8784، PMID 9642118.
"sFRP-2 is a target of the Wnt-4 signaling pathway in the developing metanephric kidney"، Dev. Dyn.، 213 (4): 440–51، 1999، doi:10.1002/(SICI)1097-0177(199812)213:4<440::AID-AJA9>3.0.CO;2-6، PMID 9853965.
"Cloning and characterization of a secreted frizzled-related protein that is expressed by the retinal pigment epithelium"، Hum. Mol. Genet.، 8 (4): 575–83، 1999، doi:10.1093/hmg/8.4.575، PMID 10072424.
"SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm"، Development، 127 (1): 109–18، 2000، PMID 10654605.
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"، Proc. Natl. Acad. Sci. U.S.A.، 99 (26): 16899–903، 2003، doi:10.1073/pnas.242603899، PMC 139241، PMID 12477932.
"The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment"، Genome Res.، 13 (10): 2265–70، 2003، doi:10.1101/gr.1293003، PMC 403697، PMID 12975309.
"The secreted frizzled related protein 2 (SFRP2) gene is a target of the Pax2 transcription factor"، J. Biol. Chem.، 278 (52): 52401–5، 2004، doi:10.1074/jbc.M305614200، PMID 14561758.
"Complete sequencing and characterization of 21,243 full-length human cDNAs"، Nat. Genet.، 36 (1): 40–5، 2004، doi:10.1038/ng1285، PMID 14702039.
"Autocrine/paracrine secreted Frizzled-related protein 2 induces cellular resistance to apoptosis: a possible mechanism of mammary tumorigenesis"، J. Biol. Chem.، 279 (15): 14602–9، 2004، doi:10.1074/jbc.M309008200، PMID 14709558.
"Methylation changes in faecal DNA: a marker for colorectal cancer screening?"، Lancet، 363 (9417): 1283–5، 2004، doi:10.1016/S0140-6736(04)16002-9، PMID 15094274.
"Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation"، Nat. Biotechnol.، 22 (6): 707–16، 2005، doi:10.1038/nbt971، PMID 15146197.
"Signal peptide prediction based on analysis of experimentally verified cleavage sites"، Protein Sci.، 13 (10): 2819–24، 2005، doi:10.1110/ps.04682504، PMC 2286551، PMID 15340161.
"The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)"، Genome Res.، 14 (10B): 2121–7، 2004، doi:10.1101/gr.2596504، PMC 528928، PMID 15489334.
"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries"، DNA Res.، 12 (2): 117–26، 2007، doi:10.1093/dnares/12.2.117، PMID 16303743.
"Alterations of the Wnt signaling pathway during the neoplastic progression of Barrett's esophagus"، Oncogene، 25 (21): 3084–92، 2006، doi:10.1038/sj.onc.1209338، PMID 16407829.
"Combination analysis of hypermethylated Wnt-antagonist family genes as a novel epigenetic biomarker panel for bladder cancer detection"، Clin. Cancer Res.، 12 (7 Pt 1): 2109–16، 2006، doi:10.1158/1078-0432.CCR-05-2468، PMID 16609023.
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks"، Cell، 127 (3): 635–48، 2006، doi:10.1016/j.cell.2006.09.026، PMID 17081983.
"Detection of aberrant methylation in fecal DNA as a molecular screening tool for colorectal cancer and precancerous lesions"، World J. Gastroenterol.، 13 (6): 950–4، 2007، doi:10.3748/wjg.v13.i6.950، PMID 17352030.
"Promoter hypermethylation of the SFRP2 gene is a high-frequent alteration and tumor-specific epigenetic marker in human breast cancer"، Mol Cancer، 7 (83): 83، 2008، doi:10.1186/1476-4598-7-83، PMC 2613402، PMID 18990230.

بوابة طب
بوابة علم الأحياء الخلوي والجزيئي
بوابة الكيمياء الحيوية

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[1] "Entrez Gene: SFRP2 secreted frizzled-related protein 2"، مؤرشف من الأصل في 5 ديسمبر 2010.

[2] "SARPs: A family of secreted apoptosis-related proteins"، Proc Natl Acad Sci U S A، 94 (25): 13636–41، يناير 1998، doi:10.1073/pnas.94.25.13636، PMC 28358، PMID 9391078.

التصنيفات الطبية	OMIM ID: 604157
المعرفات الخارجية	Ensembl Transcript ID: ENST00000274063