Growth-hormone-releasing hormone receptor

The growth-hormone-releasing hormone receptor (GHRHR) is a G-protein-coupled receptor that binds growth hormone-releasing hormone. The GHRHR activates a Gs protein that causes a cascade of cAMP via adenylate cyclase.[5] GHRHR is distinct from the growth hormone secretagogue receptor (also known as the ghrelin receptor), where growth hormone releasing peptides act to release growth hormone (without stimulating GH synthesis).

GHRHR
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGHRHR, GHRFR, GRFR, IGHD1B, growth hormone releasing hormone receptor, IGHD4
External IDsOMIM: 139191 MGI: 95710 HomoloGene: 640 GeneCards: GHRHR
Orthologs
SpeciesHumanMouse
Entrez

2692

14602

Ensembl

ENSG00000106128

ENSMUSG00000004654

UniProt

Q02643

P32082

RefSeq (mRNA)

NM_000823
NM_001009824

NM_001003685

RefSeq (protein)

NP_000814

NP_001003685

Location (UCSC)Chr 7: 30.94 – 30.99 MbChr 6: 55.35 – 55.37 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene, expressed in the pituitary, encodes a receptor for growth-hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth-hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. Many alternate transcriptional splice variants encoding different isoforms have been described, but only two have been characterized to date.[6]

Ligands

Agonists

Antagonists

References

  1. GRCh38: Ensembl release 89: ENSG00000106128 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000004654 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Gaylinn BD (2002). "Growth hormone releasing hormone receptor". Receptors & Channels. 8 (3–4): 155–62. doi:10.1080/10606820213679. PMID 12529933.
  6. "Entrez Gene: GHRHR growth hormone releasing hormone receptor".
  7. Kovács M, Schally AV, Zarándi M, Groot K (1997). "Inhibition of GH release of rats by new potent antagonists of growth hormone-releasing hormone (GH-RH)". Peptides. 18 (3): 431–8. doi:10.1016/S0196-9781(96)00334-8. PMID 9145432. S2CID 24368945.
  8. Banks WA, Morley JE, Farr SA, Price TO, Ercal N, Vidaurre I, Schally AV (Dec 2010). "Effects of a growth hormone-releasing hormone antagonist on telomerase activity, oxidative stress, longevity, and aging in mice". Proceedings of the National Academy of Sciences of the United States of America. 107 (51): 22272–7. Bibcode:2010PNAS..10722272B. doi:10.1073/pnas.1016369107. PMC 3009756. PMID 21135231.

Further reading


This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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