Latrophilin

Latrophilins are a group of highly conserved G-protein coupled receptors from the adhesion G protein-coupled receptor family. These receptors were originally identified based on their ability to bind to a component of black widow spider venom known as alpha-latrotoxin.[1] This conserved family of membrane proteins has up to three homologues in chordate species, including humans.[2]

Latrophilin
Identifiers
SymbolLatrophilin
PfamPF02354
InterProIPR003334
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
EGF, latrophilin and seven transmembrane domain containing 1
Identifiers
SymbolELTD1
Alt. symbolsETL
NCBI gene64123
HGNC20822
RefSeqNM_022159
UniProtQ9HBW9
Other data
LocusChr. 1 p33-p32
Search for
StructuresSwiss-model
DomainsInterPro
latrophilin 1
Identifiers
SymbolLPHN1
Alt. symbolsKIAA0821, CIRL1, LEC2
NCBI gene22859
HGNC20973
RefSeqNM_014921
UniProtO94910
Other data
LocusChr. 19 p13.2
Search for
StructuresSwiss-model
DomainsInterPro
latrophilin 2
Identifiers
SymbolLPHN2
Alt. symbolsLPHH1, KIAA0786, LEC1
NCBI gene23266
HGNC18582
OMIM607018
RefSeqNM_012302
UniProtO95490
Other data
LocusChr. 1 p31.1
Search for
StructuresSwiss-model
DomainsInterPro
latrophilin 3
Identifiers
SymbolLPHN3
Alt. symbolsKIAA0768, LEC3
NCBI gene23284
HGNC20974
RefSeqNM_015236
UniProtQ9HAR2
Other data
LocusChr. 4 q13.1
Search for
StructuresSwiss-model
DomainsInterPro

The precise functions of latrophilins remain unknown.[2] Genetic defects in latrophilin genes have been associated with diseases such as attention-deficit hyperactivity disorder and cancer.[3]

Human proteins containing this domain

See also

References
  1. Kreienkamp HJ, Soltau M, Richter D, Böckers T (2002). "Interaction of G-protein-coupled receptors with synaptic scaffolding proteins". Biochem. Soc. Trans. 30 (4): 464–8. doi:10.1042/BST0300464. PMID 12196116.
  2. Silva, JP; Ushkaryov, YA (2010). "The Latrophilins, "Split-Personality" Receptors". Adhesion-GPCRS. Advances in Experimental Medicine and Biology. Vol. 706. pp. 59–75. doi:10.1007/978-1-4419-7913-1_5. ISBN 978-1-4419-7912-4. PMC 3145135. PMID 21618826.
  3. Meza-Aguilar, Diana G; Boucard, Antony A (1 January 2014). "Latrophilins updated". Biomolecular Concepts. 5 (6): 457–478. doi:10.1515/bmc-2014-0032. PMID 25429599. S2CID 207442054.
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