Somatostatin receptor
Somatostatin receptors are receptors for the ligand somatostatin, a small neuropeptide associated with neural signaling, particularly in the post-synaptic response to NMDA receptor co-stimulation/activation. Somatostatin is encoded by a CRE and is very susceptible to gene promoter region activation by transcription factor CREB.[1]
![](../I/%E2%81%B9%E2%81%B0Y-DOTATOC_Structure.jpg.webp)
Image showing somatostatin biochemical pathway complete with target cell somatostatin receptor
somatostatin receptor 1 | |||||||
---|---|---|---|---|---|---|---|
Identifiers | |||||||
Symbol | SSTR1 | ||||||
NCBI gene | 6751 | ||||||
HGNC | 11330 | ||||||
OMIM | 182451 | ||||||
RefSeq | NM_001049 | ||||||
UniProt | P30872 | ||||||
Other data | |||||||
Locus | Chr. 14 q13 | ||||||
|
somatostatin receptor 2 | |||||||
---|---|---|---|---|---|---|---|
Identifiers | |||||||
Symbol | SSTR2 | ||||||
NCBI gene | 6752 | ||||||
HGNC | 11331 | ||||||
OMIM | 182452 | ||||||
RefSeq | NM_001050 | ||||||
UniProt | P30874 | ||||||
Other data | |||||||
Locus | Chr. 17 q24 | ||||||
|
somatostatin receptor 3 | |||||||
---|---|---|---|---|---|---|---|
Identifiers | |||||||
Symbol | SSTR3 | ||||||
NCBI gene | 6753 | ||||||
HGNC | 11332 | ||||||
OMIM | 182453 | ||||||
RefSeq | NM_001051 | ||||||
UniProt | P32745 | ||||||
Other data | |||||||
Locus | Chr. 22 q13.1 | ||||||
|
somatostatin receptor 4 | |||||||
---|---|---|---|---|---|---|---|
Identifiers | |||||||
Symbol | SSTR4 | ||||||
NCBI gene | 6754 | ||||||
HGNC | 11333 | ||||||
OMIM | 182454 | ||||||
RefSeq | NM_001052 | ||||||
UniProt | P31391 | ||||||
Other data | |||||||
Locus | Chr. 20 p11.2 | ||||||
|
somatostatin receptor 5 | |||||||
---|---|---|---|---|---|---|---|
Identifiers | |||||||
Symbol | SSTR5 | ||||||
NCBI gene | 6755 | ||||||
HGNC | 11334 | ||||||
OMIM | 182455 | ||||||
RefSeq | NM_001053 | ||||||
UniProt | P35346 | ||||||
Other data | |||||||
Locus | Chr. 16 p13.3 | ||||||
|
There are five known somatostatin receptors:[2]
References
- Lou L (2016). Principles of Neurobiology. New York, NY: Garland Science, Taylor and Francis Group. pp. 109–110. ISBN 978-0-8153-4494-0.
- Hoyer D, Bell GI, Berelowitz M, Epelbaum J, Feniuk W, Humphrey PP, O'Carroll AM, Patel YC, Schonbrunn A, Taylor JE (1995). "Classification and nomenclature of somatostatin receptors". Trends Pharmacol. Sci. 16 (3): 86–8. doi:10.1016/S0165-6147(00)88988-9. PMID 7792934.
External links
- Somatostatin+Receptor at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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