Tachykinin receptor

There are three known mammalian tachykinin receptors termed NK1, NK2 and NK3. All are members of the 7 transmembrane G-protein coupled receptor family and induce the activation of phospholipase C, producing inositol triphosphate (so called Gq-coupled).

Tachykinin receptor
Identifiers
Symbol?
InterProIPR001681
tachykinin receptor 1
Identifiers
SymbolTACR1
Alt. symbolsTAC1R
NCBI gene6869
HGNC11526
OMIM162323
RefSeqNM_001058
UniProtP25103
Other data
LocusChr. 2 p13.1-p12
Search for
StructuresSwiss-model
DomainsInterPro
tachykinin receptor 2
Identifiers
SymbolTACR2
Alt. symbolsTAC2R, NKNAR
NCBI gene6865
HGNC11527
OMIM162321
RefSeqNM_001057
UniProtP21452
Other data
LocusChr. 10 q11-q21
Search for
StructuresSwiss-model
DomainsInterPro
tachykinin receptor 3
Identifiers
SymbolTACR3
NCBI gene6870
HGNC11528
OMIM162332
RefSeqNM_001059
UniProtP29371
Other data
LocusChr. 4 q25
Search for
StructuresSwiss-model
DomainsInterPro

Inhibitors of NK-1, known as NK-1 receptor antagonists, can be used as antiemetic agents, such as the drug aprepitant.[1]

Binding

The genes and receptor ligands are as follows:[2]

Receptor GenePreferred ligand
NK1TACR1substance P
NK2TACR2neurokinin A
NK3TACR3neurokinin B

(Hökfelt et al., 2001; Page, 2004; Pennefather et al., 2004; Maggi, 2000)

See also

References
  1. "Aprepitant". NICE. Retrieved 2020-05-10.
  2. Maggi CA (September 1995). "The mammalian tachykinin receptors". General Pharmacology. 26 (5): 911–44. doi:10.1016/0306-3623(94)00292-U. PMID 7557266.
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