Thiopropazate
Thiopropazate (Artalan, Dartal, Dartalan, Dartan) is a typical antipsychotic of the phenothiazine class.[1] It is a prodrug to perphenazine.
Clinical data | |
---|---|
Trade names | Artalan, Dartal, Dartalan, Dartan |
ATC code | |
Identifiers | |
| |
CAS Number |
|
PubChem CID | |
ChemSpider |
|
UNII | |
KEGG |
|
ChEBI | |
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.001.376 |
Chemical and physical data | |
Formula | C23H28ClN3O2S |
Molar mass | 446.01 g·mol−1 |
3D model (JSmol) | |
| |
| |
(verify) |
Thiopropazate is manufactured by Searle (US, UK) & Boehringer Mannheim (Germany)[2] Thiopropazate is sold by Chembase, AAA Chemistry, ZINC, AKos Consulting & Solutions, Boc Sciences, ChemFrog, and ChemMol[3]
Synthesis
The alkylation of 2-chloro-10-(3-chloropropyl)phenothiazine [2765-59-5] (1) with Piperazine (2) gives N-Desmethylprochlorperazine [40323-85-1] (3). Further alkylation with 2-Bromoethyl acetate [927-68-4] (4) gives Thiopropazate (5).
See also
References
- Buckingham J (1996). Dictionary of organic compounds. London: Chapman & Hall. p. 5148. ISBN 0-412-54090-8.
- Pharmaceutical Manufacturing Encyclopedia p. 3209
- "Thiopropazate". PubChem. United States Library of Medicine.
- John W Cusic, U.S. Patent 2,766,235 (1956 to Searle & Co).
|
D1-like |
| ||||||
---|---|---|---|---|---|---|---|
D2-like |
| ||||||
|
H1 |
| ||||
---|---|---|---|---|---|
H2 |
| ||||
H3 |
| ||||
H4 |
| ||||
|
Classes | |
---|---|
Antidepressants (Tricyclic antidepressants (TCAs)) |
|
Antihistamines |
|
Antipsychotics |
|
Anticonvulsants | |
Anticholinergics | |
Others |
|
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.