Phenazolam

Phenazolam, (Clobromazolam, DM-II-90, BRN 4550445) is a benzodiazepine derivative which acts as a potent sedative and hypnotic drug. It was first invented in the early 1980s,[1] but was never developed for medical use. It has been sold over the internet as a designer drug, first being identified in seized samples by a laboratory in Sweden in March 2016.[2][3]

Phenazolam
Clinical data
Trade names(none, designer drug)
Legal status
Legal status
Identifiers
IUPAC name
  • 8-bromo-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC17H12BrClN4
Molar mass387.7 g·mol−1
3D model (JSmol)
SMILES
  • CC1=NN=C2N1C3=C(C=C(C=C3)Br)C(=NC2)C4=CC=CC=C4Cl
InChI
  • InChI=1S/C17H12BrClN4/c1-10-21-22-16-9-20-17(12-4-2-3-5-14(12)19)13-8-11(18)6-7-15(13)23(10)16/h2-8H,9H2,1H3
  • Key:BUTCFAZTKZDYCN-UHFFFAOYSA-N

Legality

Clobromazolam was made illegal in Serbia in May 2019,[4] and in Italy in March 2020.[5]

See also

References
  1. Polívka Z, Holubek J, Metyš J, Šedivŷ Z, Protiva M (1983). "Potential hypnotics and anxiolytics: 8-Chloro-6-(2-chlorophenyl)-1-[4-(2-methoxyethyl) piperazino]-methyl-4H-s-triazolo[4,3-a]-1,4-benzodiazepine and related compounds". Collection of Czechoslovak Chemical Communications. 48 (12): 3433–43. doi:10.1135/cccc19833433.
  2. "Novel Benzodiazepines. A review of the evidence of use and harms of Novel Benzodiazepines" (PDF). Advisory Council on the Misuse of Drugs. April 2020.
  3. Wagmann L, Manier SK, Felske C, Gampfer TM, Richter MJ, Eckstein N, Meyer MR (October 2020). "Flubromazolam-Derived Designer Benzodiazepines: Toxicokinetics and Analytical Toxicology of Clobromazolam and Bromazolam". Journal of Analytical Toxicology. doi:10.1093/jat/bkaa161. PMID 33048135.
  4. ""Службени гласник РС", број 38 од 31. маја 2019" [Rulebook on determining the List of psychoactive controlled substances: 38 / 2019-121] (in Serbian). Serbian Ministry of Health.
  5. "Legislazione - MINISTERO SALUTE - Decreto ministeriale" [Legislation - MINISTRY HEALTH - Ministerial decree] (in Italian). 13 March 2020.
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