Triflubazam

Triflubazam[1] is a drug which is a 1,5-benzodiazepine derivative, related to clobazam.[2] It has sedative and anxiolytic effects, with a long half-life and duration of action.[3][4][5]

Triflubazam
Identifiers
IUPAC name
  • 1-methyl-5-phenyl-7-(trifluoromethyl)-1H-1,5-benzodiazepine-2,4(3H,5H)-dione
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC17H13F3N2O2
Molar mass334.298 g·mol−1
3D model (JSmol)
SMILES
  • FC(F)(C1=CC(N(C2=CC=CC=C2)C(CC(N3C)=O)=O)=C3C=C1)F
InChI
  • InChI=1S/C17H13F3N2O2/c1-21-13-8-7-11(17(18,19)20)9-14(13)22(16(24)10-15(21)23)12-5-3-2-4-6-12/h2-9H,10H2,1H3 Y
  • Key:DMNPCIKBNDKNTO-UHFFFAOYSA-N Y
  (verify)

See also

References
  1. US 3660381, Karl-Heinz Weber KH, Merz H, K Zeile, Giesemann R, Danneberg P, "5-Aryl-1H-1,5-benzodiazepine-2,4-diones", issued 2 May 1972, assigned to CH Boehringer Sohn AG and Co KG
  2. Lundbeck Institute (2003). "triflubazam". psychotropics.dk. Retrieved 17 November 2010.
  3. Itil TM, Akpinar S, Fink M, Polvan N, Huque M, Sungurbey K (March 1976). "Controlled clinical and quantitative EEG studies of triflubazam (ORF 8063) in patients with anxiety syndrome". Current Therapeutic Research, Clinical and Experimental. 19 (3): 307–15. PMID 5248.
  4. Csanalosi I, Pereira-Oran J, Case G, et al. (1977). "Triflubazam (ORF 8063), a new benzodiazepine in anxiety neurosis". Current Therapeutic Research. 22: 166–171.
  5. Nicholson AN, Stone BM, Clarke CH (October 1977). "Effect of the 1,5-benzodiazepines, clobazam and triflubazam, on sleep in man". British Journal of Clinical Pharmacology. 4 (5): 567–72. doi:10.1111/j.1365-2125.1977.tb00787.x. PMC 1429140. PMID 20917.
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