Ciclotizolam

Ciclotizolam[1] (WE-973) is a drug which is a thienotriazolodiazepine derivative. It is a partial agonist for the benzodiazepine site of the GABAA receptor, with similar binding affinity to related compounds like brotizolam, but a low efficacy.[2][3]

Ciclotizolam
Clinical data
ATC code
  • none
Legal status
Legal status
Identifiers
IUPAC name
  • 8-bromo-6-(o-chlorophenyl)-1-cyclohexyl-4H-5-triazolo(3,4-c)thieno(2,4-e)-1,4-diazepine
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC20H18BrClN4S
Molar mass461.81 g·mol−1
3D model (JSmol)
SMILES
  • Clc5ccccc5C/2=N/Cc1nnc(n1c3sc(Br)cc\23)C4CCCCC4
InChI
  • InChI=1S/C20H18BrClN4S/c21-16-10-14-18(13-8-4-5-9-15(13)22)23-11-17-24-25-19(26(17)20(14)27-16)12-6-2-1-3-7-12/h4-5,8-10,12H,1-3,6-7,11H2 Y
  • Key:ZOSHXIXUCKESEG-UHFFFAOYSA-N Y
 NY (what is this?)  (verify)

See also

References
  1. DE Patent 2445430
  2. Weber KH, Kuhn FJ, Böke-Kuhn K, Lehr E, Danneberg PB, Hommer D, Paul SM, Skolnick P (February 1985). "Pharmacological and neurochemical properties of 1,4-diazepines with two annelated heterocycles ('hetrazepines')". European Journal of Pharmacology. 109 (1): 19–31. doi:10.1016/0014-2999(85)90535-7. PMID 2986988.
  3. Ikeda M, Weber KH, Bechtel WD, Malatynska E, Yamamura HI (1989). "Relative efficacies of 1,4-diazepines on GABA-stimulated chloride influx in rat brain vesicles". Life Sciences. 45 (4): 349–58. doi:10.1016/0024-3205(89)90145-8. PMID 2569655.


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